| 一氧化氮对大鼠实验性肝纤维化的影响 |
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| 引用本文： | 边城,徐永红,李定国,蒋祖明,陆汉明. 一氧化氮对大鼠实验性肝纤维化的影响[J]. 中国药理学通报, 2002, 18(3): 312-314 |
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| 作者姓名： | 边城 徐永红 李定国 蒋祖明 陆汉明 |
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| 作者单位： | 1. 青岛医学院附属医院传染科,青岛,266003
2. 上海第二医科大学新华医院,上海,200092 |
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| 摘 要： | 目的 研究一氧化氮 (NO)在肝纤维化发病中的作用。方法 建立大鼠肝纤维化模型 ,给予NO前体———L 精氨酸 (L Arg)及一氧化氮合酶 (NOS)抑制剂———硝基 L 精氨酸 (L NNA) ,应用病理组织学检查、放免法及生化学方法 ,观察其对肝纤维化程度、透明质酸 (HA)含量、谷 草转氨酶 (AST)及谷 丙转氨酶 (ALT)活性的影响 ,同时测定NO、一氧化氮合酶 (NOS)水平变化。结果 NO能明显降低肝纤维化程度、HA含量、AST及ALT活性。结论 NO对大鼠具有保护肝细胞和抗肝纤维化作用
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| 关 键 词： | 一氧化氮 肝纤维化 一氧化氮合酶 |
| 文章编号： | 1001-1978(2002)02-0312-03 |
| 修稿时间： | 2001-11-20 |
Effects of nitric oxide on experimental hepatic fibrosis in rats |
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| BIAN Cheng ,XU Yong Hong ,LI Ding Guo,JIANG Zu Ming,LU Han Ming. Effects of nitric oxide on experimental hepatic fibrosis in rats[J]. Chinese Pharmacological Bulletin, 2002, 18(3): 312-314 |
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| Authors: | BIAN Cheng XU Yong Hong LI Ding Guo JIANG Zu Ming LU Han Ming |
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| Affiliation: | BIAN Cheng 1,XU Yong Hong 1,LI Ding Guo,JIANG Zu Ming,LU Han Ming |
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| Abstract: | AIM To study the role of nitric oxide (NO) in the pathogenesis of hepatic fibrosis. METHODS To establish the model of hepatic fibrosis in rats and treated with L Arg (preNO) and L NNA (NOS inhibitor). The degree of hepatic fibrosis, the levels of HA,AST,ALT determined with histology,radioimmunoassay, autochemol analysis, respectively. NO and NOS were also determined. RESULTS The degree of hepatic fibrosis, the levels of AST,ALT and HA in L Arg group were all lower than those in hepatic fibrosis control group. While the levels of HA and AST in L NNA group were higher than that in hepatic fibrosis control group. CONCLUSION NO has the function of protecting liver cells and anti hepatofibrosis liver fibrosis induced by CCl 4 in rats. |
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| Keywords: | nitric oxide hepatofibrosis nitric oxide synthetase |
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