肺癌肿瘤血管生成CT及MR灌注成像研究

目的:使用动态增强CT、MR灌注成像方法评价肺癌肿瘤血管生成。方法:对84 例肺癌分别进行动态增强CT和MR扫描,计算分析各动态增强CT、MRI参数及肿块增强特点,并与肺癌的微血管密度(MVD)作相关性分析。结果:CT、MR灌注影像可更直观的显示肺癌增强特点。动态增强CT各参数PH、M/A、灌注值、rBV与MVD呈正相关,其中灌注值与MVD相关性最高(r=0.758,P<0.0001),Pm值与MVD无相关性(r=0.298,P>0.05);动态增强MRI各参数SS、PH、E1、E2、E4 与肺癌MVD呈正相关,其中以SS与MVD相关性最强(r=0.874,P<0.01)。结论:CT、MRI灌注成像技术可获得较为全面的肺癌血供信息,有望成为评估肺癌肿瘤血管生成的新方法。

Evaluation of Pulmonary Carcinoma Angiogenesis by Dynamic Contrast-Enhanced CT and MR Functional Imaging

Objective:To investigate the effects of dynamic contrast-enhanced computed tomography(DCE-CT) and contrast-enhanced magnetic resonance (DCE-MR) in the evaluation of tumor angiogenesis in patients with plmonary carcinoma.Methods:84 patients with pulmonary carcinoma underwent DCE-CT or DCE-MR scan before operation.The perfusion imaging parameters of DCE-CT:Perfusion,PH,M/A,rBV,Pm and those of DCE-MR:SS,PH,E 1,E 2,E 4 were calculated and correlated with the microvascular density (MVD) of the carcinoma.Results:DCE-CT and DCE-MR perfusion imagings could reveal the enhancement feature of the tumor.The perfusion imaging parameters of DCE-CT:Perfusion,PH,M/A and rBV correlated positively with MVD (r=0.758,P<0.0001),and no significant correlation was found between Pm and MVD (r=0.30,P>0.05 );and there were statistically significant correlations between SS,PH,E 1,E 2,E 4 and MVD.Conclusion:DCE-CT and DCE-MR perfusion imaging technique can provide information of lung carcinoma angiogenesis,and may be used to understand and monitor tumor angiogenesis in patients with lung carcinoma.