参附脱毒胶囊联合美沙酮脱毒的疗效观察

目的:评价应用中西医结合对海洛因脱毒的疗效与不良反应。方法:将180例海洛因依赖者按入院时间先后顺序随机分为A、B两组,A组给与美沙酮口服液加参附脱毒胶囊,B组单用美沙酮,对照观察两组的疗效和不良反应。结果:在控制戒断症状方面,治疗早期,A组与B组比较无显著性差异(P﹥0.05),d4起两组比较有显著性差异(P﹤0.05),尤其在焦虑、寒战、骨骼肌肉痛、厌食、失眠、恶心呕吐记分差异有显著性或非常显著意义(P﹤0.05或P﹤0.01)。药物不良反应发生率较低。结论:美沙酮联合人参附子脱毒胶囊脱毒治疗,疗效可靠,特别利于控制后期稽延性戒断症状。药物不良反应少。

Observed the efficacy of the Chinese medicine capsule plus the methodone

Objective:To evaluate the efficacy and safety of combination of Chinese medicine(Ginseng-Strobal)and western medicine for the detoxification treatment of heroin addicts.Methods:180 cases of heroin addicts were randomly divided into two groups according to the chronological order of admission time.The group A was treated with methadone oral solution plus Antimorphpro capsule and the group B was treated with methadone oral solution only.The drug's efficacy and adverse reactions observed in the two groups.Results:In the early stage(first 3 days)of treatment,there was no significant difference(P>0.05)between group A and group B in controlling withdrawal symptoms.However,from the 4th day there was significant difference(P<0.05 or P<0.01)in scale scores between two groups,especially in controlling anxiety,shivering,muscle pain,anorexia,insomnia,nausea and vomiting.And lower incidence of adverse reactions was observed in group A.Conclusion:Administration of Antimorphpro capsule and methadone for detoxification treatment was effective and safe,especially for controlling late or protracted withdrawal symptoms.