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| 黄精多糖对骨质疏松性骨折大鼠骨代谢因子的影响 | |
| 引用本文： | 曾高峰,张志勇,鲁力,肖德强,宗少晖,熊春翔,赵玉玺. 黄精多糖对骨质疏松性骨折大鼠骨代谢因子的影响[J]. 中国组织工程研究与临床康复, 2011, 15(33). DOI: 10.3969/j.issn.1673-8225.2011.33.029 |
| 作者姓名： | 曾高峰 张志勇 鲁力 肖德强 宗少晖 熊春翔 赵玉玺 |
| 作者单位： | 1. 广西医科大学,公共卫生学院,广西壮族自治区南宁市,530021 2. 广西医科大学第一附属医院脊柱骨病外科,广西壮族自治区南宁市,530021 3. 广西医科大学,研究生学院,广西壮族自治区南宁市,530021 |
| 基金项目： | 课题受广西教育厅科研基金,广西医科大学博士后流动站科研基金 |
| 摘 要： | 背景:骨质疏松性骨折主要原因是雌激素减少所形成的高转换型骨质疏松,采用雌激素虽能够有效地治疗,但长期雌激素替代治疗会引发诸多疾病.目的:观察黄精多糖对骨质疏松性骨折大鼠骨代谢因子的影响.方法:6 月龄雌性SD 大鼠,随机分为对照组(n=8)和骨质疏松性骨折组(n=36).骨质疏松性骨折组行卵巢切除后建立骨质疏松性骨折动物模型,再以0.066 mg/kg 雌激素,400,200,100 mg/kg 黄精多糖进行灌胃,2 d/次,连续35 d.采用Elisa方法测量骨钙素、抗酒石酸酸性磷酸酶的表达.结果与结论:骨质疏松性骨折大鼠的骨钙素、抗酒石酸酸性磷酸酶的阳性表达活性升高,给予黄精多糖干预治疗后,高剂量的黄精多糖使骨钙素、抗酒石酸酸性磷酸酶的阳性表达活性下降,而在中、低剂量组干预效果不显著.说明高剂量黄精多糖对骨质疏松性骨折大鼠具有降低骨钙素、抗酒石酸酸性磷酸酶的阳性表达活性的作用,促进骨折愈合的作用. |
| 关 键 词： | 黄精多糖 骨质疏松性骨折 骨钙素 抗酒石酸酸性磷酸酶 中药单体 |
Effect of polygonatum polysaccharide on bone metabolism cytokines in osteoporotic fracture rats |
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| Zeng Gao-feng,Zhang Zhi-yong,Lu Li,Xiao De-qiang,Zong Shao-hui,Xiong Chun-xiang,Zhao Yu-xi. Effect of polygonatum polysaccharide on bone metabolism cytokines in osteoporotic fracture rats[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(33). DOI: 10.3969/j.issn.1673-8225.2011.33.029 | |
| Authors: | Zeng Gao-feng Zhang Zhi-yong Lu Li Xiao De-qiang Zong Shao-hui Xiong Chun-xiang Zhao Yu-xi |
| Affiliation: | Zeng Gao-feng1,Zhang Zhi-yong1,Lu Li1,Xiao De-qiang1,Zong Shao-hui2,Xiong Chun-xiang3,Zhao Yu-xi3 1School of Public Health,3Post-graduate School,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China,2Department of Spinal Surgery,First Affiliated Hospital of Guangxi Medical University |
| Abstract: | BACKGROUND:Onset of osteoporotic fracture is mainly resulted from reduction of estrogen that forms high-turnover osteoporosis,though this phenomenon can be treated effectively using estrogen,the long-term estrogen replacement therapy can cause many diseases.OBJECTIVE:To investigate the effect of polygonatum polysaccharide(PSP)on the cytokines of bone metabolism in the osteoporotic fracture rats.METHODS:Female,6-month aged SD rats were divided into the control(n=8)and osteoporotic fracture(n=36)groups.After ... |
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