RSJ对小鼠免疫功能的影响

目的　探讨RSJ对小鼠免疫功能的影响。方法　将小鼠随机分为生理盐水组(NS组 )、RSJ组、生理盐水 +氢化可的松组 (NS +HD组 )和RSJ+氢化可的松组 (RSJ+HD组 ) ,RSJ组和RSJ+HD组小鼠灌胃RSJ 5 .0 g/ (kg·d) ,其他 2组灌胃等容量的生理盐水 ,连续 14d ;从第 8天起 ,NS +HD组和RSJ +HD组小鼠肌注氢化可的松 0 .0 2g/ (kg·d) ,连续 7d。给药后第 15天分别测定各组小鼠的免疫器官质量、腹腔巨噬细胞吞噬功能和血清IL - 2含量 ,并进行组间比较。结果　小鼠脾脏和胸腺质量、腹腔巨噬细胞吞噬功能和血清IL - 2含量RSJ组均明显优于NS组 (P <0 .0 1和P <0 .0 5 ) ,RSJ +HD组均明显优于NS +HD组 (P <0 .0 1和P <0 0 5 )。结论　RSJ可提高小鼠的免疫功能 ,具有对抗免疫抑制的作用。

Effect of RSJ on immune function of rats

Objective It is to study the effect of RSJ on immune function of rats.Methods The rats were randomly divided into NS group, RSJ group, NS+hydrocortisone (HD) group and RSJ+HD group. Rats in RSJ and RSJ+HD groups were given RSJ by gastric perfusion at the dose of 5.0 g/(kg·d) for 14 days, and other rats were given equal volume of NS by the same way. The rats in NS+HD and RSJ+HD groups were injected hydrocortisone by 0.02 g/(kg·d) from the eighth day to fourteenth day. Then the mass of immune organ, celiac macrophage function and the content of serum IL-2 of the rats were measured and compared with each other.Results The mass of spleen and thymus, celiac macrophage function and the content of serum IL-2 in RSJ group were all better than that in NS group (P<0.05,P<0.01), and that in RSJ+HD group were better than that in NS+HD group (P<0.01, P<0.05).Conclusion RSJ can improve the immune function of rats and can decrease the immunosuppressive effect.