| 不同压力持续气道正压对单肺通气氧化应激反应的影响 |
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| 引用本文： | 赵晓玲,曾小莉,谢冲,杨永慧,高昌俊,蒯建科,于代华,柴伟,姚立农. 不同压力持续气道正压对单肺通气氧化应激反应的影响[J]. 临床麻醉学杂志, 2010, 26(11) |
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| 作者姓名： | 赵晓玲 曾小莉 谢冲 杨永慧 高昌俊 蒯建科 于代华 柴伟 姚立农 |
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| 作者单位： | 第四军医大学唐都医院麻醉科; |
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| 摘 要： | 目的比较不同压力持续气道正压(CPAP)对单肺通气氧化应激反应的影响。方法择期行食管癌根治术患者48例,随机均分为双肺通气组(A组)、单肺通气组(B组)、单肺通气非通气肺给予2cmH2OCPAP组(C组)及5cmH2OCPAP组(D组)。分别于开胸前(T0)、单肺通气后(A组于开胸后)30min(T1)、90min(T2)、150min(T3)、手术结束(T4)时测定血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)、NO浓度。结果 T1～T4时B、C组及T2～T4时D组的SOD活性明显低于A组,T1～T4时B、C、D组MDA及NO浓度高于A组(P0.05)。T1～T4时C、D组MDA及NO浓度均显著低于B组(P0.05),T3时C、D组SOD活性显著高于B组(P0.05);T3时D组MDA及NO浓度高于C组(P0.05)。结论 CPAP能减轻单肺通气氧化应激反应,且2cmH2OCPAP优于5cmH2OCPAP。
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| 关 键 词： | 持续气道正压 单肺通气 氧化应激 |
Effects of continuous positive airway pressure at different levels on oxidative stress during one lung ventilation |
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| ZHAO Xiao-ling,ZENG Xiao-li,XIE Chong,et al.. Effects of continuous positive airway pressure at different levels on oxidative stress during one lung ventilation[J]. The Journal of Clinical Anesthesiology, 2010, 26(11) |
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| Authors: | ZHAO Xiao-ling ZENG Xiao-li XIE Chong et al. |
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| Affiliation: | ZHAO Xiao-ling,ZENG Xiao-li,XIE Chong,et al.Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China |
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| Abstract: | Objective To compare the effects of continuous positive airway pressure (CPAP) at different levels of pressure on oxidative stress during one-lung ventilation.Methods Forty-eight patients undergoing elective radical esophageal cancer resection were randomly divided into four groups with 12 cases each:two-lung ventilation group (group A),one-lung ventilation group (group B),2 cm H2O CPAP group (group C),5 cm H2O CPAP group (group D). Venous blood samples were taken before induction (T0),at 30 min (T1),90 min... |
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| Keywords: | Continuous positive airway pressure One-lung ventilation Oxidative stress |
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