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影响复方茶碱片脆碎度因素的分析
引用本文:张春峰,罗亚杰,石晓莹,袁淑杰.影响复方茶碱片脆碎度因素的分析[J].黑龙江医药,2002,15(5):353-354.
作者姓名:张春峰  罗亚杰  石晓莹  袁淑杰
作者单位:1. 哈药集团制药四厂,150070
2. 哈尔滨健尔制药厂
3. 哈药集团总公司
摘    要:目的研究影响复方茶碱片脆碎度的各种因素,为生产提供控制方法。方法根据QC理论,对生产过程进行人、机、物、法、环分析,找出主要影响因素。结果因素的不同水平对脆碎度的影响程度不同。结论原料的结晶、辅料、粘合剂、湿混合时间和压片机型号是影响脆碎度的主要因素。

关 键 词:片剂  脆碎度  颗粒
修稿时间:2002年1月7日

The analysis of friability effect factor in manufacture of compound theophylline tablets
Zhang Chunfeng,No Fourth Pharmaceutical Factory,Harbin Pharmaceutical Grop Holding Co.,Ltd.The analysis of friability effect factor in manufacture of compound theophylline tablets[J].Heilongjiang Medicine,2002,15(5):353-354.
Authors:Zhang Chunfeng  No Fourth Pharmaceutical Factory  Harbin Pharmaceutical Grop Holding Co  Ltd
Affiliation:Zhang Chunfeng,No Fourth Pharmaceutical Factory,Harbin Pharmaceutical Grop Holding Co.,Ltd 150070
Abstract:OBJECTIVE Study the influence compound thophylline tablets tablets various factor of friability, makes a living the product method of control providing. METHODS According to QC's theory, person, machine, body, method and the environment are carried on to the opposite product course is analysed, and looks for out chiefly influencing the factor. RESULTS The differ- ent standards of factor are different to the influence level of friability. CONCLUSION It is the major factor that influences fragile brokenly to spend that the crystal of raw material, subsidiary material, binder and wet mixes ime and pressure piece type name.
Keywords:Tablets  Friability  Grain
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