C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie,the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity |
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Authors: | Xu Pang Li-Ping Kang Xiao-Mei Fang He-Shui Yu Li-Feng Han Yang Zhao Li-Xia Zhang Li-Yan Yu Bai-Ping Ma |
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Affiliation: | 1.Beijing Institute of Radiation Medicine,Beijing,China;2.Tianjin University of Traditional Chinese Medicine,Tianjin,China;3.Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;4.Yunnan Branch of Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Jinghong,China |
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Abstract: | Twenty-three new C21 steroidal glycosides, marstenacissides C1–C10 (1–10), D1–D7 (11–17) and E1–E6 (18–23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots of Marsdenia tenacissima. The chemical structures of all compounds were established by spectroscopic techniques, including high-resolution mass spectrometry and NMR spectroscopy, as well as by comparison with reported spectral data. The anti-HIV activities of these compounds were screened, and the compounds obtained displayed inhibitory effects against HIV-1 with inhibition rates of 36.4–81.3% at 30 μM. |
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