| Fah~(-/-)小鼠对NTBC的药物依赖性观察 |
| |
| 引用本文： | 彭雨婷,武昕,孔祥平,李绍林,刘光泽.Fah~(-/-)小鼠对NTBC的药物依赖性观察[J].中国比较医学杂志,2014,24(11):1-5. |
| |
| 作者姓名： | 彭雨婷 武昕 孔祥平 李绍林 刘光泽 |
| |
| 作者单位： | 解放军第458医院全军肝病中心转基因工程室 |
| |
| 基金项目： | 国家重点基础研究发展计划（973计划） |
| |
| 摘 要： | 目的观察Fah-/-小鼠对NTBC的药物依赖性,更详尽的掌握该模型的生物学特征,使该模型得以更有效的利用。方法 Fah-/-小鼠NTBC停药后,观察小鼠体重变化、生存状态、生存时间,定期取样记录血清学和肝脏病理学变化。结果 NTBC停药后,Fah-/-小鼠体重进行性下降,活力降低,5~7周死亡,期间伴随着ALT、AST等血清指标的升高及肝细胞严重变性及大量坏死。结论 Fah-/-小鼠需终身服用NTBC,依赖性强,停药会出现严重肝损伤,表明该模型是研究酪氨酸血症Ⅰ型和其他肝损伤的理想模型。
|
| 关 键 词： | Fah^-/-小鼠 NTBC 肝损伤 酪氨酸血症I型 |
| 修稿时间： | 2014/10/22 0:00:00 |
To observe the NTBC dependence of Fah-knockout mice |
| |
| PENG Yu-ting,WU Xin,KONG Xiang-ping,LI Shao-lin and LIU Guang-ze.To observe the NTBC dependence of Fah-knockout mice[J].Chinese Journal of Comparative Medicine,2014,24(11):1-5. |
| |
| Authors: | PENG Yu-ting WU Xin KONG Xiang-ping LI Shao-lin and LIU Guang-ze |
| |
| Affiliation: | Key Laboratory of Transgenic Engineering, Center of Infectious Diseases, 458th Hospital of PLA, Guangzhou 510602, China |
| |
| Abstract: | Objective To observe the NTBC dependence of Fah-knockout mice and study the biological characteristics in order to use the model more effectively. Methods Examine the progressive changes in body weight, survival time, liver pathology and serological markers after the NTBC withdrawal. Results After removing of NTBC, Fah-knockout mice lost their body weight gradually, and finally died in 5 to 7 weeks, along with increased serum ALT, AST levels and deformation of the hepatocytes. Conclusions Fah-knockout mice have a strong drug dependence of NTBC and could be the ideal model to hereditary tyrosinemia type I and other liver injury. |
| |
| Keywords: | Fah-knockout mice NTBC Liver failure Tyrosinemia type I |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国比较医学杂志》浏览原始摘要信息 |
|
点击此处可从《中国比较医学杂志》下载全文 |
|
