Cholinergic nucleus basalis neurons may influence the cortex via the thalamus |
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| Authors: | A I Levey A E Hallanger B H Wainer |
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| Affiliation: | 1. Department of Cell Physiology, Max-Planck-Institute for Medical Research, 69120 Heidelberg, Germany;2. Department of Neurology, Columbia University College of Physicians and Surgeons, NY, USA;3. Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany;4. Department of Psychiatry and Systems Neurophysiology Group, Central Institute of Mental Health, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany;5. Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria, Australia;6. Department of Neuropaediatrics, University Hospital Giessen, Feulgenstraße 10-12, 35392 Gießen, Germany |
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| Abstract: | The cholinergic neurons of the nucleus basalis of Meynert have been shown to provide the major cholinergic innervation of the cerebral cortex through which cholinergic transmission may modulate cortical activity. This study describes a projection from the cholinergic and non-cholinergic neurons of the nucleus basalis to the reticular nucleus of the thalamus, and a projection from the brainstem cholinergic neurons to the reticular nucleus as well as to other thalamic nuclei. The projection from the nucleus basalis to the reticular nucleus, which itself is synaptically interconnected with other thalamic nuclei, may provide an additional pathway for the modulation of cortical activity by the cholinergic basal forebrain and brainstem groups. |
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