Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency |
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Authors: | F Altare A Durandy D Lammas JF Emile S Lamhamedi F Le Deist P Drysdale E Jouanguy R D?ffinger F Bernaudin O Jeppsson JA Gollob E Meinl AW Segal A Fischer D Kumararatne JL Casanova |
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Affiliation: | INSERM U429, H?pital Necker-Enfants Malades, Paris 75015, France. |
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Abstract: | In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion. |
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