神经元特异性烯醇化酶预测及评价心肺脑复苏后患者脑损害的临床意义

目的探讨心肺复苏患者神经元特异性烯醇酶水平的变化对脑损害临床意义。方法选取2010年1月至2012年12月收住本院ICU55例非神经系统疾病引起心跳骤停经心肺复苏抢救后的患者,其中32例自主循环恢复（ROSC）,23例经抢救未恢复ROSC。检测采用电化学发光免疫测定法,对患者复苏后3h、6h、12h、24h血清NSE的浓度检测。结果心脏骤停患者血清NSE的浓度均高于正常值,且ROSC未恢复组远高于ROSC恢复组（P〈0.05）,ROSC恢复组与ROSC未恢复组差异有统计学意义。结论早期测定血清NSE水平对心肺复苏患者脑损害预后评价具有一定的临床意义,血清NSE可作为心肺复苏成功与否的检测指标。

Neuron specific enolase of prediction and evaluation of cardiopulmonary cerebral resuscitation in patients after brain damage and its clinical significance

Objective To investigate patients with cardiopulmonary resuscitation neuron specific enolase level changes on brain damage clinical significance. Methods From 2010 January-2012 year in December received my courtyard ICU55 cases of nervous system diseases caused by cardiac arrest cardiopulmonary resuscitation after menopause patients, including 32 cases of restoration of spontaneous circulation （ROSC）, 23 cases of percutaneous salvage of failing to restore ROSC. Detected by electrochemiluminescence immunoassay, on patient recovery after 3 h, 6 h, 12 h, 24 h and serum NSE concentration detection. Results Cardiac arrest in patients with serum NSE concentrations were higher than the normal value, and the ROSC did not restore group is much higher than that of ROSC recovery group （P0.05）, ROSC recovery group and ROSC did not restore group and the difference was statistically significant. Conclusion Early determination of serum NSE levels on cardiopulmonary resuscitation in patients with brain injury prognosis evaluation has certain clinical meaning, serum NSE can be used as a cardiopulmonary resuscitation success indicator.