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A randomised controlled trial of SMS messaging and calendar reminders to improve vaccination timeliness in infants
Affiliation:1. Kirby Institute, University of New South Wales, Kensington, NSW, Australia;2. National Centre for Immunisation Research and Surveillance, The Children’s Hospital at Westmead, Westmead, NSW, Australia;3. Kids Research Institute, The Children’s Hospital Westmead, Westmead, NSW, Australia;4. Vaccinology and Immunology Research Trials Unit, Women’s and Children’s Hospital, and Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia;5. National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT, Australia;6. Department of Health, South Australia, Adelaide, SA, Australia;1. Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA;2. Center for Health Literacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA;1. Department of Community Health Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;2. Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;3. Yoiko-no Shounika Sato, Niigata, Japan;4. Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;5. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan;1. Department of Political Science, Stanford University, United States;2. Immunization Program, Vermont Department of Health, United States;3. School of Global and Public Affairs, IE University, Spain;4. Department of Government, Dartmouth College, United States;1. Department of Pediatrics, University of Colorado Anschutz Medical Campus, B065, 13123 E. 16th Ave., Aurora, CO 80045, USA;2. Center for Global Health, Colorado School of Public Health, A090, 13199 E. Montview Blvd., Suite 310, Aurora, CO 80045, USA;3. Center for Health Studies, Universidad del Valle de Guatemala, 18 Av. 11-95, Zona 15, Vista Hermosa III, Guatemala City, Guatemala;4. Department of Community and Behavioral Health, Colorado School of Public Health, B119, 13001 E. 17th Place, Aurora, CO 80045, USA;5. Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado Anschutz Medical Campus, F443, 13199 E. Montview Blvd., Suite 300, Aurora, CO 80045, USA;6. Center for Human Development at the Southwest Trifinio, Finca Mojarras, Aldea Los Encuentros, Caballo Blanco, Retalhuleu, Guatemala;7. Department of Epidemiology, Colorado School of Public Health, B119, 13001 E. 17th Place, Aurora, CO 80045, USA;1. Adult and Child Consortium for Outcomes Research and Delivery Science Program (ACCORDS), Children’s Hospital Colorado, University of Colorado Denver, USA;2. Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA;3. Department of Family Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA;1. UCD School of Economics, Dublin, Ireland;2. UCD Geary Institute for Public Policy, University College Dublin, Dublin, Ireland;3. UCD School of Psychology, University College Dublin, Dublin, Ireland
Abstract:BackgroundThe effectiveness of SMS reminders in improving vaccination coverage has been assessed previously, with effectiveness varying between settings. However, there are very few studies on their effect on the timeliness of vaccination.DesignUnblinded, randomised controlled trial with blocked sampling.Methods1594 Australian infants and young children were recruited to assess the impact of (1) SMS reminders only, (2) a personalised calendar, (3) SMS reminder and personalised calendar and (4) no intervention, on receipt of vaccine within 30 days of the due date. Outcomes were measured for receipt of vaccines due at 2, 4, 6, 12 and 18 months of age. A post-hoc assessment was also conducted of the impact of a new national “No jab No Pay” policy introduced during the trial, which removed philosophical objections as an exemption for financial penalties for non-vaccination.ResultsThere was a statistically significant improvement in on-time vaccination only at the 12 month schedule point amongst infants who received SMS reminders alone (RR 1.09, 95% CI 1.01–1.18) or in combination with a personalised calendar (1.11, CI 1.03–1.20) compared to controls. This impact was limited to participants who had received one or more previous doses late. No statistically significant impacts of calendar interventions alone were seen. There was a high rate of on-time compliance amongst control participants − 95%, 86%, 80%, 74% at the 4, 6, 12 and 18 month schedule points respectively, which increased more than 10 percentage points after implementation of the “No Jab, No Pay” policy.ConclusionsSMS reminders are more effective in improving timeliness where pre-existing compliance is lower, but the 18 month schedule point appeared to be less amenable to intervention. Australia and New Zealand Clinical Trial Registration No. ACTRN12614000970640.
Keywords:Text messaging  Immunization programs  Reminder systems
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