| 不同浓度氮酮对黄芩苷体外透皮吸收的影响 |
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| 引用本文： | 吕志平,刘强,等.不同浓度氮酮对黄芩苷体外透皮吸收的影响[J].第一军医大学学报,2002,22(11):1003-1004. |
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| 作者姓名： | 吕志平 刘强 |
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| 摘 要： | 目的：研究氮酮对黄芩苷体外透皮吸收的影响。方法：以裸鼠皮肤为实验屏障，观察氮酮浓度（体积比）分别为0、2％，4％，6％，8％，10％时黄芩苷透皮吸收速率常数。结果：氮酮浓度为0，2％，4％，6％，8％，10％时黄芩苷的透皮吸收速率常数分别为76．07％，89．23，167．36，238．61，200．45，171．49ug.cm^-2.H^-1。结论：氮酮可以促进黄芩苷的透皮吸收，在实验浓度范围内，氮酮浓度为6％时有最大的透皮速率常数。
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| 关 键 词： | 黄芩苷 氮酮 经皮给药 透皮吸收 动物实验 |
Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro] |
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| Zhi-Ping L,Qiang Liu,Xin-Wei Lu.Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro][J].Journal of First Military Medical University,2002,22(11):1003-1004. |
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| Authors: | Zhi-Ping L Qiang Liu Xin-Wei Lu |
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| Affiliation: | Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China. |
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| Abstract: | OBJECTIVE: To study the effects of azone on the percutaneous absorption of baicalin in vitro. METHODS: Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined. RESULTS: The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%. CONCLUSION: C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%. |
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