早期应用尼可地尔对STEMI患者行急诊介入治疗中慢血流的预防价值

目的 评估早期应用尼可地尔对急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)中慢血流的预防价值.方法 收集自2018年1月至2019年12月于北京京煤集团总医院胸痛中心收治的188例STEMI并行急诊PCI的患者为研究对象,随机分为尼可地尔组(n=86)和常规治疗组(n=102).观察比较两...

Preventive effect of early nicorandil administration on slow flow in STEMI patients HF emergency PCI

Objective To review the preventive effect of early nicorandil administration on slow flow in acute ST-segment elevation myocardial infarction(STEMI)after emergency PCI.Methods STEMI patients undergone emergency PCI(n=188)were chosen from Center of Chest Pain in General Hospital of Beijing Jingmei Group from Jan.2018 to Dec.2019,and divided randomly into nicorandil group(n=86)and routine group(n=102).The percentage of slow flow phenomenon related to infarction was observed and compared in 2 groups during PCI.The indexes of peak value of cardiac troponin,brain natriuretic peptide(BNP),heart failure(HF)classification and length of stay(LOS)were collected from patients after PCI.The differences in incidence rate of slow flow and relevant laboratory indexes were counted and analyzed between 2 groups.Results The peak value of cardiac troponin and LOS after PCI decreased significantly in nicorandil group compared with routine group(P<0.05).The results of multi-factor Logistic regression analysis showed that early nicorandil administration was an effective preventive factor against slow flow during PCI(OR=0.157,95%CI:0.052~0.474,P<0.001).Conclusion It is preliminarily verified that early nicorandil administration can effectively prevent slow flow during PCI,reduce myocardial infarction area and cut down LOS.