中国原发性高血压患者ACE/ID多态性荟萃分析

目的对国人血管紧张素Ⅰ转换酶(ACE)基因内含子16插入(Ⅰ)/缺失(D)多态性与原发性高血压的关联性进行荟萃(Meta)分析.方法以原发性高血压组和健康对照组基因型分布的OR值为统计量.全面检索相关文献,剔除不符合要求的文献,排除发表偏倚的影响 ,应用REVMAN3.1 软件对各研究结果进行一致性检验和数据合并.结果 18个相关文献结果差异无显著性.研究共包括原发性高血压组1 612例,健康对照组1 710例,合并DD/(ID+Ⅱ) O R(95%可信区间)为1.37(1.15～1.63),P<0.01.结论国人(汉族人为主)ACE/ID多态性的DD基因型与原发性高血压危险性增加有关联.

Meta-analysis on the association of ACE/ID polymorphism and essential hypertension in Chinese population

OBJECTIVE: To study on the association of the insertion(I)/deletion(D) polymorphism of the angiotensin-converting enzyme gene intron 16 (ACE/ID) and essential hypertension(EH) in Chinese population by the means of meta-analysis. METHODS: Odds ratios of ACE/ID genotype distributions in EH patients against healthy control were analysed. All the relevant studies were identified, poor-qualified studies were eliminated, and the risk of publication bias was excluded. The meta-analysis software, REVMAN3.1, was applied for investigating heterogeneity among individual studies and summarising effects across studies. RESULTS: A total of 1,612 cases and 1,710 controls from 18 studies were included. No heterogeneity among the studies has been found. The frequencies of the ACE DD, ID and II genotypes were 23%, 41%, and 36% in cases and 19%, 46% and 35% in controls respectively. The pooled odds ratio (with 95% CI) of DD vs ID + II is 1.37(1.15-1.63) (P < 0.01), while the pooled odds ratio of II vs ID + DD is 0.96 (0.83-1.12) (P > 0.05). CONCLUSION: In Chinese population (mainly the Hans), DD genotype is associated with the increased risk of EH.