| 非酒精性脂肪性肝病在2型糖尿病患者中的患病率及其危险因素研究 |
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| 引用本文： | 高建勤,张晶,季宇,胡逢来,杨婧.非酒精性脂肪性肝病在2型糖尿病患者中的患病率及其危险因素研究[J].中国全科医学,2011,14(20). |
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| 作者姓名： | 高建勤 张晶 季宇 胡逢来 杨婧 |
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| 作者单位： | 北京航天总医院内分泌科,北京市,100076 |
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| 基金项目： | 北京市首都医学发展科研基金 |
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| 摘 要： | 目的 了解非酒精性脂肪性肝病(NAFLD)在2型糖尿病(T2DM)患者中的患病率,并分析其危险因素.方法 选取312例T2DM患者为研究对象,检测所有对象的肝肾功能、血糖、胰岛素、血脂等生化指标,并计算胰岛素抵抗指数(HOMA-IR).由超声诊断NAFLD.结果 T2DM患者中NAFLD患病率为47.0%(147/312).T2DM伴NAFLD组患者的腰围、体质量、体质指数(BMI)均显著高于单纯T2DM组,差异有统计学意义(P＜0.01).T2DM伴NAFLD组患者空腹胰岛素、三酰甘油水平、HOMA-IR、尿微量清蛋白(MALB)、合并代谢综合征的比例均显著高于单纯NAFLD组,差异有统计学意义(P＜0.05).结论 NAFLD在T2DM患者中患病率高,超重、腹型肥胖、高三酰甘油血症、高胰岛素血症是其发生的危险因素.
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| 关 键 词： | 糖尿病 2型 非酒精性脂肪性肝病 胰岛素抵抗 危险因素 |
Frequency and Risk Factors of Nonalcoholic Fatty Liver Disease among Type 2 Diabetic Patients |
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| GAO Jian-qin,ZHANG Jing,JI Yu,et al..Frequency and Risk Factors of Nonalcoholic Fatty Liver Disease among Type 2 Diabetic Patients[J].Chinese General Practice,2011,14(20). |
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| Authors: | GAO Jian-qin ZHANG Jing JI Yu |
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| Affiliation: | GAO Jian-qin,ZHANG Jing,JI Yu,et al.Department of Endocrinology,Beijing Aerospace Hospital,Beijing 100076,China |
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| Abstract: | Objective To investigate the frequency and risk factors of non-alcoholic fatty liver disease(NAFLD) in patients with type 2 diabetes mellitus.Methods Blood samples of 312 patients were collected for assessment of glycemic and lipid profiles,liver enzymes,and HOMA-IR.The diagnosis of NAFLD was established by ultrasound.Results NAFLD was diagnosed in 47.0% of patients with higher waist circumference,body weight,and BMI(P<0.01).The levels of triglycerides,insulin,and HOMA-IR were significantly higher in T2DM p... |
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| Keywords: | Diabetes mellitus type 2 Nonalcoholic fatty liver disease Insulin resistance Risk factors |
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