| 白芍总苷对小鼠系统性红斑狼疮样改变的保护作用 |
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| 引用本文： | 周玲玲,魏伟,沈玉先,徐叔云.白芍总苷对小鼠系统性红斑狼疮样改变的保护作用[J].中国药理学通报,2002,18(2):175-177. |
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| 作者姓名： | 周玲玲 魏伟 沈玉先 徐叔云 |
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| 作者单位： | 1. 南京中医药大学工理学教研室,南京,210029
2. 安徽医科大学临床药理研究所,合肥,230032 |
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| 摘 要： | 目的 观察白芍总苷 (TGP)对空肠弯曲菌CJ S13 1诱导的小鼠SLE样改变的保护作用。方法 采用空肠弯曲菌CJ S13 1和CFA混合免疫动物 ,诱导小鼠SLE样改变。结果 TGP 5 0 ,10 0 ,2 0 0mg·kg-1·d-1× 2 8d ,ig能部分或完全拮抗血清IgG型自身抗体水平的升高 ,抑制ConA及LPS诱导的淋巴细胞增殖反应的增强和IL 1生成的增多。结论 一定剂量的TGP对小鼠SLE样改变具有一定的保护作用
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| 关 键 词： | 红斑狼疮 系统性 免疫调节 白芍总苷 空肠弯曲菌 |
| 文章编号： | 1001-1978(2002)02-0175-03 |
The effects of TGP on CJ-S131-induced systemic lupus erythematosus -like model in mice |
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| ZHOU Ling Ling ,WEI Wei,SHEN Yu Xian,XU Shu Yun.The effects of TGP on CJ-S131-induced systemic lupus erythematosus -like model in mice[J].Chinese Pharmacological Bulletin,2002,18(2):175-177. |
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| Authors: | ZHOU Ling Ling WEI Wei SHEN Yu Xian XU Shu Yun |
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| Affiliation: | ZHOU Ling Ling 1,WEI Wei,SHEN Yu Xian,XU Shu Yun |
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| Abstract: | AIM To investigate the effects of TGP on immunologic changes associated with CJ S 131 induced SLE like model in mice. METHODS SLE like syndrome was induced by injection of CJ S 131 and CFA.Various doses of TGP were given by gavage once daily for 28 days. RESULTS The levels of IgG anti single stranded DNA(ssDNA) and histone autoantibodies were increased in sera four weeks after injection.The proliferation response of splencytes to ConA and LPS and the production of IL 1 were also increased. TGP(50,100,200 mg·kg -1 ·d -1 ,ig) inhibited the aboved changes of SLE like mouse model partly or completely. CONCLUSION The SLE mouse model was similar to idiopathic SLE in humans. TGP has modulating effects on alternations of immunity of SLE like mouse model. |
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| Keywords: | lupus erythematosus systemic immunomodulation TGP CJ S 131 |
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