| 一次和分次电离辐射诱发LACA小鼠的肿瘤实验研究 |
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| 引用本文： | 赵乃坤,杜维霞,刘秀敏.一次和分次电离辐射诱发LACA小鼠的肿瘤实验研究[J].中华放射医学与防护杂志,1982,2(1):28-32. |
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| 作者姓名： | 赵乃坤 杜维霞 刘秀敏 |
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| 作者单位： | 卫生部工业卫生实验所;卫生部工业卫生实验所;卫生部工业卫生实验所 |
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| 摘 要： | 进行了一次或分次钴-60γ线(或吕线)全身照射诱发LACA小鼠肿瘤的实验研究。在一年的实验观察中, γ线一次全身照射300拉德组肿瘤发生率最高(52.5%), 是对照组的4.3倍。分次照射100拉德×3和150拉德×4组, 虽然后者胸腺淋巴瘤发生率增加, 但是肿瘤的总发生率并不高于一次γ线300拉德照射组。这可能与分次照射剂量偏低、间隔时间稍长或观察时问较短等诸因素有关。粒细胞白血病小鼠骨髓细胞体外软琼脂培养和染色体分析进一步证明了白血病的发生是起因于造血干细胞的缺陷、分化异常、以致幼雅细胞大量堆积这一观点。
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EXPERIMENTAL STUDIES ON INDUCTION OF TUMORS IN LACA MICE EXPOSED TO SINGLE AND FRACTl0NATED IRRADIATl0NS |
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| Zhao Naikun,Du Weixia and Liu Xiumin.EXPERIMENTAL STUDIES ON INDUCTION OF TUMORS IN LACA MICE EXPOSED TO SINGLE AND FRACTl0NATED IRRADIATl0NS[J].Chinese Journal of Radiological Medicine and Protection,1982,2(1):28-32. |
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| Authors: | Zhao Naikun Du Weixia and Liu Xiumin |
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| Affiliation: | Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing;Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing;Department of Biological Effect of Radiation, Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing |
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