| 熊果酸-3’-取代丙醇酯衍生物的合成及抗肿瘤活性研究 |
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| 引用本文： | 李霞,白雪,吴科,王裕军,石万棋,李颖,尹述凡.熊果酸-3’-取代丙醇酯衍生物的合成及抗肿瘤活性研究[J].有机化学,2012(4):703-708. |
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| 作者姓名： | 李霞 白雪 吴科 王裕军 石万棋 李颖 尹述凡 |
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| 作者单位： | 1. 四川大学化学学院 成都610064
2. 四川国康药业有限公司 成都610041 |
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| 摘 要： | 熊果酸与1,3-二溴丙烷反应制得中间体熊果酸-3’-溴代丙醇酯(1),含溴醇酯1与含氮化合物反应,合成了系列熊果酸含氮衍生物2a～2j,均未见文献报道,其结构经1H NMR,13C NMR,IR,MS确认.初步的抗肿瘤生物活性研究表明,部分化合物的抗肿瘤活性与熊果酸相比均有提高,其中化合物2e具有更强的抑制活性.
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| 关 键 词： | 熊果酸 3’-溴代丙醇酯 合成 抗肿瘤 |
Synthesis and Antitumor Activities of 3(')-Substituted Propanolursolates |
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| Li, Xia
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Bai, Xue
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Wu, Ke
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Wang, Yujun
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Shi, Wangqi
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Li, Ying
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Yin, Shufan.Synthesis and Antitumor Activities of 3(')-Substituted Propanolursolates[J].Chinese Journal of Organic Chemistry,2012(4):703-708. |
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| Authors: | Li Xia Bai Xue Wu Ke Wang Yujun Shi Wangqi Li Ying Yin Shufan |
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| Affiliation: | Li,Xiaa Bai,Xuea Wu,Kea Wang,Yujuna Shi,Wangqib Li,Ying,a Yin,Shufan,a(aCollage of Chemistry,Sichuan University,Chengdu 610064)(bSichuan Guokang Pharmaceutical Co.,Ltd,Chengdu 610041) |
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| Abstract: | 3’-Substituted propanolursolates(1) were obtained by a reaction of ursolic acid with trimethylene bromide.This intermediate reacted with several N-containing compounds to afford a series of new derivatives 2a～2j.The structures of new products were characterized by means of1H NMR,13C NMR,IR and MS techniques.The preliminary bioassay test shows that several compounds give a good antitumor activity,and most of them are better than that of parent ursolic acid.Among them,compound 2e shows the best activity. |
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| Keywords: | ursolic acid 3’-substituted propanolursolate synthesis antitumor activity |
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