孟鲁司特治疗小儿急性荨麻疹的临床疗效观察

目的:观察孟鲁司特治疗小儿急性荨麻疹的有效性和安全性。方法:采用前瞻性随机对照的方法,将44例急性荨麻疹的患儿随机分为治疗组(25例)和对照组(19例),治疗组口服孟鲁司特,每日1次;对照组口服氯雷他定,每日1次,两组疗程均为3日。两组患儿均同时给予基础治疗(口服维生素C、西米替丁,搔痒严重者予维丁胶性钙和苯海拉明肌注)。结果:治疗组总有效率92％,对照组总有效率79％,两组疗效无显著性差异(X2=0.65,P>0.05)。结论:孟鲁司特治疗小儿急性荨麻疹,疗效与氯雷他定相当,且副作用少,值得临床推广应用。

The Therapeutic Effect Assessment of Montelukast in Children with Acute Urticaria

Objective: To evaluate the safety and effect of montelukast in children with acute urticaria. Methods: 44 children with acute urticaria were randomly divided into two groups. One group was 25 cases treated with montelukast once a day for 3 days. The other group (19 cases) was control group, treated with claritadine for 3 days. Both of two groups were on the basic tradition therapy(such as Vitamin C, Cimetidine, CCO or Benadryl). Results: The total effective rates of the group with montelukast was 92%, and the control group was 79%. There was no systematic significant difference in statistics(x2=0.65, P > 0.05). Conclusion: Compared to claritadine, montelukast was safety and effect in children with acute urticaria.