| 太赫兹时域光谱技术及其在药学领域的应用 |
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| 引用本文： | 刘囡,徐开俊,周建平,马金龙,金飚兵. 太赫兹时域光谱技术及其在药学领域的应用[J]. 药学进展, 2008, 32(9): 398-406 |
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| 作者姓名： | 刘囡 徐开俊 周建平 马金龙 金飚兵 |
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| 作者单位： | 1. 中国药科大学药剂学教研室,江苏,南京,210009
2. 南京大学电子系,江苏,南京,210093 |
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| 摘 要： | 介绍了太赫兹时域光谱技术在氨基酸类、糖类、嘌呤嘧啶类、蛋白质和肽类等物质的分析鉴别及不同晶型和手性药物分辨中的应用情况。首次公布了室温下N-乙酰氨基葡萄糖在0.2～2.5 THz波段的太赫兹时域光谱,表明其特征吸收峰位于1.33 THz和1.76 THz处。展望了太赫兹时域光谱技术在药学领域的应用前景。
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| 关 键 词： | 太赫兹时域光谱 特征峰 药物分析 |
The Application of THz Time-Domain Spectroscopy in Pharmaceutical Field |
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| LIU Nan,XU Kai-jun,ZHOU Jian-ping,MA Jin-long,JIN Biao-bing. The Application of THz Time-Domain Spectroscopy in Pharmaceutical Field[J]. Progress in Pharmaceutical Sciences, 2008, 32(9): 398-406 |
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| Authors: | LIU Nan XU Kai-jun ZHOU Jian-ping MA Jin-long JIN Biao-bing |
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| Affiliation: | LIU Nan, XU Kai-jun, ZHOU Jian-ping , MA Jin-long, JIN Biao-bing (1. Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; 2. Department of Electronics, Nanjing University, Nanjing 210009, China) |
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| Abstract: | The application of THz time-domain spectroscopy （THz-TDS） in studying amino acids, saccharides, purines or pyridines, protein and polypeptides, and in distinguishing them from the different crystal forms and from chiral compounds was introduced. For the first time, the THz-TDS of N-Acetylglucosamine at room temperature and in the frequency range 0.2-2.5 THz, and with absorption peaks at 1.33 THz and 1.76 THz was reported. Furthermore, the application perpective of THz-TDS in pharmaceutical field was also prospected. |
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| Keywords: | THz time-domain Spectroscopy Characteristic peak Pharmaceutical analysis |
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