Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum) |
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| Authors: | Olusegun S Ajala Andrew M PiggottFabien Plisson Zeinab KhalilXiao-cong Huang Sunday A AdesegunHerbert AB Coker Robert J Capon |
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| Affiliation: | a Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
b Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The University of Lagos, CMUL/LUTH Campus, PMB12003 Idiaraba-Surulere, Lagos, Nigeria |
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| Abstract: | Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized. |
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| Keywords: | Indole alkaloids Hunteria umbellata Nigerian medicinal plant Natural products chemistry |
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