| 大鼠腹腔点燃性癫痫模型的建立 |
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| 引用本文： | 唐玉红,谢杨高,柴慧霞,陈启贤.大鼠腹腔点燃性癫痫模型的建立[J].四川大学学报(医学版),1990(3). |
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| 作者姓名： | 唐玉红 谢杨高 柴慧霞 陈启贤 |
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| 作者单位： | 华西医大生理学教研室
(唐玉红，谢杨高，柴慧霞)，华西医大生理学教研室(陈启贤) |
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| 摘 要： | 作者用阈下剂量的马桑内酯进行反复腹腔注射,造成大鼠点燃性癫痫模型,为癫痫的研究提供了一种新的实验工具。在本实验条件下,每日给大鼠1次注射马桑内酯1.25mg/kg或1.75mg/kg所建立的癫痫模型较好。
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| 关 键 词： | 癫痫 腹腔注射 马桑内酯 点燃模型 大鼠 |
A Kinding Model of Epilepsy Induced by Intraperitoneal Injection of Coriaria Lactone in Rats |
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| Tang Yuhong,Xie Yanggao,Chai Huixia,Chen Qixian.A Kinding Model of Epilepsy Induced by Intraperitoneal Injection of Coriaria Lactone in Rats[J].Journal of West China University of Medical Sciences,1990(3). |
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| Authors: | Tang Yuhong Xie Yanggao Chai Huixia Chen Qixian |
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| Affiliation: | Tang Yuhong;Xie Yanggao;Chai Huixia;Chen Qixian Department of Physiology |
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| Abstract: | Fifty adult male Sprague-Dawley ratswere divided into five groups.Intraperi-toneal injections of various doses of cori-aria lactone (CL, 0.75, 1.25, 1.75, and 2.0mg/kg) and normal saline were given res-pectively per 2 days. The behavior of therats was observed and the ECoG wasrecorded by telemetric method. The results of experiments show thatsi kindling model of epilepsy can be estab-lished by intraperitoneal injection of CLAn rats.This chronic experimental modelis of value for application because it iseasily established and the rate of beingkindled is relatively high, but the morta-lity is low, and the kindling effect canlast well.The model can avert the patho-logical change caused by artificial injury tobrain,so it is advantageous to the researchon neurochemistry and ultrastructure. In our experimental condition, it isoptimal to select 1.25mg/kg or 1. 75mg/kgas the dosage of CL for establishingkindling model. |
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| Keywords: | Epilepsy Intraperitoneal injection Coriaria lactone kindling model Rats |
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