| 辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的干预研究 |
| |
| 引用本文： | 杨宇红,曹东华,刘溯,周海英,曹梅芳.辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的干预研究[J].药学服务与研究,2008,8(4):269-271. |
| |
| 作者姓名： | 杨宇红 曹东华 刘溯 周海英 曹梅芳 |
| |
| 作者单位： | 上海市长宁区中心医院老年科,上海,200336 |
| |
| 摘 要： | 目的：探讨辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的影响。方法：收集86例确诊为高脂血症的病人，随机分为试验组（49例）和对照组（ST例）。两组病人均给予相似饮食以及等剂量阿法骨化醇和复方氨基酸螯合钙，试验组在此基础上加用辛伐他汀40mg／d，疗程3个月。于用药前、用药后3个月分别采集静脉血测定骨代谢指标及检查骨密度。结果：试验组和对照组病人用药后总碱性磷酸酶（TAP）及骨源性碱性磷酸酶（BAP）均有明显升高（P〈0．01或P〈0．05），试验组TAP及BAP比对照组用药后升高更显著（P〈0．05）。试验组和对照组用药后尿脱氧吡啶啉与肌酐的比值、骨宽频超声衰减值差异均无统计学意义。结论：辛伐他汀短期内对骨形成的生化指标有促进作用，因时间较短，对骨吸收的生化指标和骨密度的影响尚无统计学意义，有待进一步研究。
|
| 关 键 词： | 辛伐他汀 骨疾病 代谢性 老年人 碱性磷酸酶 尿脱氧吡啶啉与肌酐比值 |
Effect of simvastatin on bone metabolism in elderly patients with osteopenia and hyperlipemia |
| |
| YANG Yu-hong,CAO Dong-hua,LAU Su,ZHOU Hai-ying,CAO Mei-fang.Effect of simvastatin on bone metabolism in elderly patients with osteopenia and hyperlipemia[J].Pharmaceutical Care and Research,2008,8(4):269-271. |
| |
| Authors: | YANG Yu-hong CAO Dong-hua LAU Su ZHOU Hai-ying CAO Mei-fang |
| |
| Affiliation: | YANG Yu-hong,CAO Dong-hua,LIU Su,ZHOU Hai-ying,CAO Mei-fang(Department of Geriatrics,Central Hospital of Changning District of Shanghai,Shanghai 200336,China) |
| |
| Abstract: | Objective:To investigate the effect of simvastatin on bone metabolism in elderly patiants with osteopenia and hyperlipemia.Methods:Eighty-six elderly patients with osteopenia and hyperlipemia were enrolled and randomized into treatment group(49 cases) and control group(37 cases).All subjects received equi-dosage alfacalcidol and compound calcium amino acid chelate capsules.The patients in treatment group additionally received simvastatin tablets(40 mg/d) for 3 months.The biochemical indicators of bone metab... |
| |
| Keywords: | simvastatin bone diseases metabolic aged alkaline phosphatase ratio of urine deoxypyridinoline to creatinine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
