血糖、血压水平对2型糖尿病患者血管内皮损伤的影响

目的：探讨血糖、血压水平对2型糖尿病（T2DM）患者内皮损伤的影响。方法：采用ELISA分别测定正常对照（NC）、T2DM、高血压病（EH）、T2DM＋EH4组，血糖控制较好的T2DM、T2DM＋EH；血糖控制较差的T2DM、T2DM＋EH4组，轻度EH、EH＋T2DM；中重度EH、EH＋T2DM4组患者血浆血管性血友病因子百分含量（vWF％）。结果：vWF％：T2DM组（115．81±38．5）％、EH组（112．97±32．4）％、T2DM＋EH组（133．77±42．7）％均高于NC组（92．29±23．9）％；T2DM＋EH组分别高于T2DM组、EH组，差异具有统计学意义（P〈0．05）。血糖控制较差的T2DM＋EH组（145．01±33．99）％均高于血糖控制较好的T2DM组（106．84±40．56）％、T2DM＋EH组（114．70±35．12）％及血糖控制较差的T2DM组（112．36±28．19）％，差异具有统计学意义（P〈0．05）。中、重度EH＋T2DM组（143．36±45．84）％均高于轻度EH组（93．50±13．95）％、EH＋T2DM组（116．83±37．10）％，差异具有统计学意义（P〈0．05）。结论：T2DM、EH患者存在内皮功能损伤，T2DM＋EH患者内皮功能受损较单纯T2DM组、EH组更严重。T2DM＋EH患者既要控制血糖、又要控制血压才能减少血管并发症。

Effects of blood glucose and blood pressure on endothelium function in patients with type 2 diabetes mellitus

Objective： To investigate the effects of blood glucose and blood pressure on endothelium function in patients of T2DM. Methods： Plasma vWF percentage content （vWF%） was measured by ELISA in the following groups： NC, T2DM, EH and T2DM ＋EH group; well-controled T2DM and T2DM ＋EH , poorly-controled T2DM and T2DM＋EH group; mild EH and EH＋T2DM , moderate-severe EH and EH＋ T2DM group. Results： vWF% in group T2DM （115.81 ± 38.56）%, EH （112.97±32.47）% and T2DM＋EH （133.77±42.75） % were higher than that in NC （92.29 ±23.97 ）% group （all P〈0.05）. vWF % in group T2DM＋EH was higher than that in group T2DM and EH （both P〈0.05）. vWF % in group of glucose poorlycontrolled T2DM＋EH （145.01± 33.99）% was highest among well-controled T2DM （106.84 ± 40.56）%, T2DM＋EH（ 114.70±35.12）% and poorly-controled T2DM （112.36± 28.19）% （P〈0.05）. vWF % in group of moderate-severe EH ＋T2DM （ 143.36±45.84 ） % was higher than that in mild EH group （ 93.50±13.95 ） % and EH＋T2DM group （116.83 ±37.10）% （P〈0.05）. Conclusion： There is endothelium dysfunction in T2DM and EH patients. Endothelium dysfunction in T2DM＋ EH patients is more severe than that in T2DM and EH patients. Inorder to reduce vascular complications, blood glucose and blood pressure shoud be controled strictly in patients of T2DM with hypertention.