| 免疫PET显像在肿瘤诊疗中的研究进展 |
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| 引用本文： | 张迪,陈虞梅,赵海涛,王成,魏伟军,刘建军. 免疫PET显像在肿瘤诊疗中的研究进展[J]. 中华核医学与分子影像杂志, 2022, 0(2) |
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| 作者姓名： | 张迪 陈虞梅 赵海涛 王成 魏伟军 刘建军 |
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| 作者单位： | 上海交通大学医学院附属仁济医院核医学科 |
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| 基金项目： | 上海市青年科技启明星计划 (20QA1406100)。 |
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| 摘 要： | 免疫PET显像是一种新型分子影像模式,其有机结合了单克隆抗体的高特异性与PET显像的高灵敏度。近年来,免疫PET显像探针的临床转化应用日渐增多,其可实现对多种肿瘤的早期无创诊断、抗体治疗患者分层以及放射免疫治疗的精准剂量评估。该文对免疫PET显像在肿瘤诊疗方面的研究进展进行了总结。
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| 关 键 词： | 抗体,单克隆 抗体 纳米技术 正电子发射断层显像术 发展趋势 |
Recent advancement of clinical immunoPET imaging in tumor diagnosis and therapy |
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| Zhang Di,Chen Yumei,Zhao Haitao,Wang Cheng,Wei Weijun,Liu Jianjun. Recent advancement of clinical immunoPET imaging in tumor diagnosis and therapy[J]. Chinese Journal of Nuclear Medicine, 2022, 0(2) |
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| Authors: | Zhang Di Chen Yumei Zhao Haitao Wang Cheng Wei Weijun Liu Jianjun |
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| Affiliation: | (Department of Nuclear Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China) |
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| Abstract: | ImmunoPET imaging,which combining the specificity of monoclonal antibody and high sensitivity of PET imaging,blazes new trails of molecular imaging modality.In recent years,clinical translation and application of immunoPET imaging strategies have been flourishing,as a result,facilitating early and non-invasive diagnosis of numerous human tumors,patient stratification before monoclonal antibody therapy and radiation dose estimation prior to radioimmunotherapy.Here,we summarize the most recent clinical evidence of immunoPET in tumor diagnosis and therapy. |
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| Keywords: | Antibodies,monoclonal Antibodies Nanotechnology Positron-emission tomography Trends |
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