重症急性胰腺炎高血糖控制研究

目的:探讨重症急性胰腺炎(SAP)高血糖控制方法。方法:采用低精蛋白锌胰岛素(NPH)皮下注射、胰岛素持续皮下注射(CSII)、甘精胰岛素皮下注射方法,观察入院5d内低血糖及高血糖次数、血糖控制水平。结果:血糖≤4.0mmol·L-1及血糖≥11.1mmol·L-1的发生率,CSII组、甘精胰岛素组与NPH组比较,P<0.01或P<0.05;入院第3天每日最高血糖,CSII组与NPH组、甘精胰岛素组比较,P<0.01或P<0.05;入院第5天每日最高血糖,CSII组、甘精胰岛素组与NPH组比较,P<0.01或P<0.05。结论:甘精胰岛素、CSII用于控制SAP的高血糖,优于NPH,甘精胰岛素、CSII效果相近。

Control of Hyperglycemia in Patients with Severe Acute Pancreatitis

OBJECTIVE: To discuss the the control of hyperglycemia in patients with severe acute pancreatitis(SAP).METHODS: Patients were treated with NPH(subcutaneous injection) or continuous subcutaneous insulin injection(CSII) or Insulin glargine(subcutaneous injection).Incidences of hypoglycemia and hyperglycemia and the blood sugar level within 5 days of admission were measured.RESULTS: The incidences of blood glucose level being ≤4.0 mmol·L-1 or ≥11.1 mmol·L-1 were significant different in CSII group and insulin glargine group compared with NPH group respectively(P<0.01 or P<0.05).In CSII group compared with NPH or Insulin Glargine group respectively on the 3rd day of admission,the highest blood glucose level was significant different(P<0.01 or P<0.05).In CSII and Insulin Glargine groups compared with NPH respectively on the 5th day of admission,the highest blood glucose level was significant different(P<0.01 or P<0.05).CONCLUSION: Insulin Glargine and CSII were similar in efficacy and superior to NPH in treating hyperglycemia in patients with SAP.