CO2气腹对血浆内皮素和NO浓度的影响

目的：观察CO2气腹对血浆NO和内皮素（ET）浓度的影响。方法：选择20例择期行腹腔镜胆囊切除术（LC）患者，分别于麻醉前，气腹前，气腹后3min及结束气腹后5min抽取静脉血，测定血浆ET和NO的含量。结果：气腹后平均动脉压（MAP）和ET含量显著高于诱导和气腹前，NO含量较气腹前明显降低。结论：LC患者CO2气腹后MAP升高，NO，ET分泌失衡，并参与了血压的调节。

Effects of carbon dioxide pneumoperitoneum on concentration of plasma endothelin and nitric oxide during laparoscopic cholecystectomy

Objective To investigate the effects of carbon dioxide pneumoperitoneum on concentration of plasma endothelin(ET) and nitric oxide(NO) during laparoscopic cholecystectomy. Methods Twenty patients undergoing laparoscopic cholecystectomy were selected. The intravenous blood samples were taken before general anesthesia, insufflation,3 minutes after insufflation, 5 minutes after desufflation to determine the plasma content of ET and NO. Results Compared with those before induction of general anaesthesia and insufflation, mean arterial pressure(MAP) and the plasma ET concentration were increased siginificantly, and the plasma NO concentration reduced siginificantly. Conclusion The carbon dioxide pneumoperitoneam during laparoscopic cholecystectomy increase MAP and adjust blood pressure with the unbalanced secretion of NO and ET.