| 淫羊藿总黄酮对维A酸诱导大鼠骨质疏松症的防治作用 |
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| 引用本文： | 季晖,刘康,李绍平.淫羊藿总黄酮对维A酸诱导大鼠骨质疏松症的防治作用[J].中国药科大学学报,2000,31(3):64-67. |
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| 作者姓名： | 季晖 刘康 李绍平 |
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| 作者单位： | [1]中国药科大学药理学教研室 [2]中国药科大学中药药理学教研室 |
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| 基金项目： | 本课题系江苏省科委应用基础基金资助项目 |
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| 摘 要： | 以９０ｍｇ／ｋｇ维Ａ酸结合低钙饲料诱导大鼠有质疏松症，模型组在鼠血清碱性碳酸酶（ｓ－ＡＬＰ）生碱性磷酸酶（ＨＩＳ－ｓ－ＡＬＰ）显著升高，股骨、胫骨骨重（Ｗ）下降，骨表观线密度（Ｗ／Ｌ）、表观面密度（Ｗ／ＬＤ）、骨灰重（Ｗａｓｈ）、灰分表观线密度（Ｗａｓｈ／Ｌ）及灰分表观面密度（Ｗａｓｈ／ＬＤ）明显降低。淫羊萑总黄酮７５、１５０、３００ｍｇ／ｋｇ连续给药一个月，可降低模型大鼠的Ｓ－ＡＬＰ与ＨＩＳ－Ｓ
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| 关 键 词： | 骨质疏松症 淫羊藿总黄酮 维A酸 防治 |
| 修稿时间： | 2000-01-14 |
Effect of HEF on
Osteoporosis Induced by Retinoic Acid in Male Rats |
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| JI Hui LIU Kang LI Shao-Ping,GONG Xiao-Jian.Effect of HEF on
Osteoporosis Induced by Retinoic Acid in Male Rats[J].Journal of China Pharmaceutical University,2000,31(3):64-67. |
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| Authors: | JI Hui LIU Kang LI Shao-Ping GONG Xiao-Jian |
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| Affiliation: | JI Hui
(Department of Pharmacology)
LIU Kang
(Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical
University,Nanjing 210009,China)
LI Shao-Ping ,GONG Xiao-Jian
(Department of Pharmacology) |
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| Abstract: | Rat osteoporosis models induced by Retinoic Acid(RA)cooperated with low calcium fodder were used to evaluate the function of HEF. Three doses of HEF(75,150 and 300 mg/kg)were given for one month by oral administration. Compared with model group, HEF could decrease s ALP and HIS s ALP, increase Ca and P content of femur. 300 mg/kg HEF could raise s Ca,increase W/L and W/LD of femur and tibia and femur weight and femur matrix apparent area density( W matrix / LD ). |
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| Keywords: | Osteoporosis Total flavonoids of \%Herba Epimedii\%(HEF) Retinoic Acid Bone apparent line density Bone apparent area density |
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