| 硝酸舍他康唑泡腾胶囊的制备工艺和含量测定 |
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| 引用本文： | 金从形,黄微微,杜有功,陈赛贞,徐珊珊,张英.硝酸舍他康唑泡腾胶囊的制备工艺和含量测定[J].中国临床药学杂志,2010(2):111-114. |
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| 作者姓名： | 金从形 黄微微 杜有功 陈赛贞 徐珊珊 张英 |
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| 作者单位： | 浙江三门县中医院药剂科;温州医学院药学院;浙江恩泽医药公司;浙江台州医院药剂科; |
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| 基金项目： | 温州医学院药学院2008届毕业生,现已在浙江恩泽医药公司工作 |
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| 摘 要： | 目的研究硝酸舍他康唑泡腾胶囊的制备工艺及含量测定。方法确定处方的组成，制备泡腾胶囊，并用紫外分光光度法测定硝酸舍他康唑的含量。结果紫外分光光度法测定硝酸舍他康唑含量的标准曲线为A=0．0075p＋0．0096（r=0．9997），在质量浓度10～90mg·L^-1内吸光度与质量浓度之间的线性关系良好。结论该泡腾胶囊的制备方法简单，用紫外分光光度法测定含量，方法可靠。
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| 关 键 词： | 硝酸舍他康唑 泡腾胶囊 含量测定 紫外分光光度法 |
Preparation and assaying of sertaconazole nitrate effervescent capsules |
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| JIN Congxing,HUANG Weiwei,DU Yougong,CHEN Saizhen,XU Shanshan,ZHANG Ying.Preparation and assaying of sertaconazole nitrate effervescent capsules[J].Chinese Journal of Clinical Pharmacy,2010(2):111-114. |
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| Authors: | JIN Congxing HUANG Weiwei DU Yougong CHEN Saizhen XU Shanshan ZHANG Ying |
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| Affiliation: | 1Department of Pharmacy/a>;Traditional Chinese Medicine Hospital of Sanmen/a>;Sanmen 317100/a>;China/a>;2Department of Pharmacy/a>;Taizhou Hospital/a>;Linhai 317000/a>;China |
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| Abstract: | AIM To study the preparation and assaying method of sertaconazole nitrate effervescent capsules. METHODS The sertaconazole nitrate effervescent capsules were prepared and the assaying method with ultraviolet spectrophotometry was established after the formulation was eonfimed. RESULTS The standard curve of sertaconazole nitrate was A = 0.007 5p ＋ 0.009 6,with a good linearity（ r = 0.999 7） in the range of 10 - 90 mg·L^-1. CONCLUSION The preparation method is simple and the assaying method with ultraviolent spectrophotometry is reliable. |
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| Keywords: | sertaconazole nitrate effervescent capsule determination of content ultraviolet spectrophotometry |
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