ATP结合盒转运蛋白A1研究进展

动脉粥样硬化是心脑血管疾病的重要基础病理改变，而胆固醇在巨噬细胞内聚集和泡沫细胞形成是动脉粥样硬化的始动环节。ATP结合盒转运蛋白Al（ABCAl）是一种重要的胆固醇流出调节蛋白，能介导细胞内胆固醇逆向转运到细胞外，使之与载脂蛋白A-Ⅰ结合并包装形成高密度脂蛋白（HDL）的膜转运蛋白。因此，ABCAl是调节血浆HDL及细胞内胆固醇水平的重要膜蛋白，ABCAl的表达水平与动脉粥样硬化的发生关系密切。同时，细胞内脂质、核受体PPAR、LXR、RXR和细胞因子等对ABCAl蛋白表达具有凋控作用。本文将ABCAl研究进展作一综述。

The research progress of ATP-binding cassette transporter A1

Atherosclerosis is a significant basic pathological change of cardiovascular and cerebrovascular diseases. The accumulation of cholesterol in macrophages and the formation of foam cells are the initial step of atherosclerosis. ATP-binding cassette transporter A1 （ ABCA1 ） is an important cholesterol efflux regulatory protein. ABCA1 mediates the reverse transportation of cholesterol which incorporates with ApoA-Ⅰ to form high density lipoprotein （HDL） across cellular membranes, thus, ABCA1, the expression level of which has a close relationship with atherosclerosis, is an important membrane protein that modulates the level of plasma HDL and intracellular cholesterol, Intracellular lipids, nuchear receptor PPAR, LXR, RXR and cytoline are regulatory factors of ABCA1 expression.