| 用脑内透析法测定人参茎叶皂甙及其单体对大鼠纹状体DOPAC、HVA及5-HIAA的影响 |
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| 引用本文： | 张予阳,于庆海,吴春福. 用脑内透析法测定人参茎叶皂甙及其单体对大鼠纹状体DOPAC、HVA及5-HIAA的影响[J]. 中药药理与临床, 1991, 0(1) |
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| 作者姓名： | 张予阳 于庆海 吴春福 |
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| 作者单位： | 沈阳药学院中药药理教研室，沈阳药学院中药药理教研室，沈阳药学院中药药理教研室 沈阳 110015，沈阳 110015，沈阳 110015 |
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| 摘 要： | 用脑内透析法结合高效液相——电化学检测技术的研究发现人参茎叶皂式和单体皂甙Rg_1、Rh_1可显著降低清醒自由活动大鼠脑纹状体细胞外液中DOPAC和HVA的含量,而对5-HIAA却无显著影响。Rg_2和Re对DOPAC、HVA和5-HIAA则均无显著影响。
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| 关 键 词： | 人参茎叶皂甙(GSLS) 人参皂甙Rg_1 人参皂甙Rg_2 人参皂甙Re 人参皂甙Rh_1 脑内透析 纹状体 3 4--二羟苯乙酸 高香草酸 5-羟吲哚乙酸 |
Effect of GSLS and its monomers on DOPAC, HVA and 5-HIAA in rat striatum in vivo |
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| Zhang Yuyang,Yu Qinghai,Wu Chunfu. Effect of GSLS and its monomers on DOPAC, HVA and 5-HIAA in rat striatum in vivo[J]. Pharmacology and Clinics of Chinese Materia Medica, 1991, 0(1) |
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| Authors: | Zhang Yuyang Yu Qinghai Wu Chunfu |
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| Abstract: | An in vivo dialysis technique for determination of endogenous neurotransmitters and their metabolites was studied.Extracellular dopamine (DA) , 3, 4 -dihydroxyphenylacetic acid (DOPAC)and homovanillic acid(HVA), as well as serotonin's metabolite 5-hydroxy-indole-3-acetic acid (5-HIAA), in striatum of the freely moving rat were measured directly by HPLC coupled with electrochemical detection. There was a marked decrease of DOPAC and HVA after GSLS (200mg/kg ip) ,Rg1 (20mg/kg ip) and Rh1 (20mg/kg ip) treatment.No effect of the three drugs on 5 -HIAA was showed. No effect of Re(20 mg/kg ip) and Rg2 (20mg/kg ip)on DOPAC, HVA and 5-HIAA was showed either. |
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| Keywords: | Ginseng stem-leaves saponins (GSLS) Ginsenoside-Rg_1 Rg_2 Re Rh_1 brain dialysis striatum DOPAC 5-HIAA HVA |
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