| 应用伊曲康唑预防化疗后继发真菌感染的疗效 |
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| 引用本文： | 王春燕,吴秉毅,郭坤元.应用伊曲康唑预防化疗后继发真菌感染的疗效[J].南方医科大学学报,2003,23(4):389-390. |
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| 作者姓名： | 王春燕 吴秉毅 郭坤元 |
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| 作者单位： | 第一军医大学珠江医院血液科,广东,广州,510282 |
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| 摘 要： | 目的探讨应用伊曲康唑预防恶性血液病化疗后继发真菌感染的疗效。方法将入院治疗的114例恶性血液病患者随机分为对照组及预防用药组,观察2组发生真菌感染的次数。结果用伊曲康唑预防组,52例仅2例并发真菌感染,继发真菌感染率为仅为3.8%。而对照组62例中,8例发生真菌感染,真菌发生为12.8%,两组比较,统计学有显著差异(P<0.05)。结论化疗前口服伊曲康唑可以减少恶性血液病患者化疗后并发真菌的感染率。
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| 关 键 词： | 伊曲康唑 真菌感染 恶性血液病 |
| 文章编号： | 1000-2588(2003)04-0389-02 |
| 修稿时间： | 2002年11月16 |
A controlled clinical trial of itraconazole for prevention of fungal infections secondary to chemotherapy |
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| WANG Chun-yan,WU Bing-yi,GUO Kun-yuan.A controlled clinical trial of itraconazole for prevention of fungal infections secondary to chemotherapy[J].Journal of Southern Medical University,2003,23(4):389-390. |
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| Authors: | WANG Chun-yan WU Bing-yi GUO Kun-yuan |
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| Affiliation: | WANG Chun-yan,WU Bing-yi,GUO Kun-yuan Department of Hematology,Zhujiang Hospital,First Military Medical University,Guangzhou 510282,China |
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| Abstract: | To study the preventive effect of itraconazole against fungal infections following chemotherapy in tumor patients, we conducted a double-blind randomized clinical trial in 114 tumor patients receiving chemotherapy, who were divided into itraconazole treatment group (n=52) and control group (n=62) and the incidences of fungal infections after chemotherapy were recorded. In comparison with the control group, itraconazole treatment group exhibited a significant decrease in fungal infection episodes (12.8% vs3.8%), illustrating the efficacy of itraconazole treatment as a preventive measure against fungal infections secondary to chemotherapy. |
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| Keywords: | itraconazole fungal infections neoplastic diseases |
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