| 不同剂量巴曲酶对大鼠局灶性脑缺血再灌流后热休克蛋白70 mRNA的影响 |
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| 引用本文： | 苏志强,李国霖,刘亢丁,饶明俐,盛利,赵庆杰.不同剂量巴曲酶对大鼠局灶性脑缺血再灌流后热休克蛋白70 mRNA的影响[J].中国急救医学,1999,19(9):0. |
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| 作者姓名： | 苏志强 李国霖 刘亢丁 饶明俐 盛利 赵庆杰 |
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| 作者单位： | 1. 哈尔滨医科大学第一临床医学院神经内科,150001
2. 白求恩医科大学第一临床医学院神经内科 |
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| 摘 要： | 目的 探讨不同剂量巴曲酶对大鼠局灶性脑缺血再灌流保护作用。方法 采用线栓法制备大脑中动脉缺血再灌流模型。利用ＲＴ－ ＰＣＲ 方法检测缺血脑组织ＨＳＰ７０ ｍＲＮＡ 相对含量。结果 与对照组相比，巴曲酶组ＨＳＰ７０ ｍＲＮＡ 水平明显增加（ Ｐ＜ ０ ．０１） ，且随着用药剂量增加其呈上升趋势。结论 巴曲酶对脑缺血有保护作用，能使ＨＳＰ７０ ｍＲＮＡ 表达上调。
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| 关 键 词： | 巴曲酶 脑缺血再灌流 热休克蛋白 |
| 文章编号： | 1002-1949(1999)09-0515-02 |
Influence of different dosages Batroxobin on heat shock protein 70 mRNA in rat with focal cerebral ischemia and reperfusion |
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| SU Zhi-qiang,LI Guo-lin,LIU Kang-ding,et al..Influence of different dosages Batroxobin on heat shock protein 70 mRNA in rat with focal cerebral ischemia and reperfusion[J].Chinese Journal of Critical Care Medicine,1999,19(9):0. |
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| Authors: | SU Zhi-qiang LI Guo-lin LIU Kang-ding |
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| Affiliation: | SU Zhi-qiang,LI Guo-lin,LIU Kang-ding,et al.Department of Neurology,First Teaching Hospital,Harbin Medical University,Harbin 150001,China |
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| Abstract: | Objective To study the protective effect of different dosage Batroxobin after cerebral ischemic reperfusion.Methods The local cerebral ischemic reperfusion model with thread embolism of MCA was made.RT-PCR method was used to study the expression of HSP70.Results The level of HSP70mRNA in Batroxobin groups was increased as compared with control group.Furthermore,the relative value of HSP70 mRAN was ascended as Batroxobin dosages increased.Conclusion Batroxobin had significantly protective effect and could induce upregulation of HSP70 mRNA expression. |
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| Keywords: | Batroxobin Cerebral ischemic reperfusion Heat shock protein |
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