| 重组腺病毒AdCD体外抑瘤作用的研究 |
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| 引用本文： | 李芳芳,李冬田,佟惠春,李菲,李光明. 重组腺病毒AdCD体外抑瘤作用的研究[J]. 天津医药, 2002, 30(5): 291-294 |
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| 作者姓名： | 李芳芳 李冬田 佟惠春 李菲 李光明 |
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| 作者单位： | 300070,天津医科大学微生物学教研室 |
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| 摘 要： |
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| 关 键 词： | 肿瘤 基因治疗 重组腺病毒 AdCD 体外抑瘤作用 研究 |
Study of Antitumor Effect of Recombinant Adenovirus AdCD/5-FC in Vitro |
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| LI Fangfang,LI Ebngtian,TONG Huichun,et al. Study of Antitumor Effect of Recombinant Adenovirus AdCD/5-FC in Vitro[J]. Tianjin Medical Journal, 2002, 30(5): 291-294 |
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| Authors: | LI Fangfang LI Ebngtian TONG Huichun et al |
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| Affiliation: | LI Fangfang,LI Ebngtian,TONG Huichun,et al Department of Microbiology,Tianjin Medical University 300070 |
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| Abstract: | Objective: To study the antitumor effect of recombinant adenovirus AdCD/5-FC in vitro. Methods: AdCD was constructed by cotransfection of 293 cells by shuttle plasmid pAdEICMV and cutted AdLacZ DNA. Then it was used to inhibit the cell growth of mammary cancer, cancer of lung and cervical carcinoma in vitro with prorug 5-FC. At the same time, its by stander effect was observed. Results: AdCD/5-FC therapeutic system had an extremely strong antitumor effect on mammary cancer, cancer of lung and cervical carcinoma in vitro. It also had an obvious by stander effect. Conclusion: The Ad-CD/5-FC therapeutic system may be regarded as a strategy of gene therapy for local control of growth of tumor cells susceptible to 5-FC. |
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| Keywords: | gene therapy cytidine deaminase adenoviridae genes tumor cells cultured |
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