| 含羟基和咪唑基团新手性肽核酸的设计与合成 |
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| 引用本文： | 孟庆国,许笑宇,梁远军,刘克良. 含羟基和咪唑基团新手性肽核酸的设计与合成[J]. 有机化学, 2006, 26(6): 845-847 |
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| 作者姓名： | 孟庆国 许笑宇 梁远军 刘克良 |
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| 作者单位： | 1. 烟台大学药学院,烟台,264005
2. 军事医学科学院毒物药物研究所,北京,100850 |
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| 摘 要： | 以含丝氨酸和组氨酸残基的手性肽核酸单体替换经典肽核酸单体, 采用固相合成方法设计合成了五个新序列含羟基和咪唑基团的10聚体手性肽核酸, 经ESI-MS或MALDI-TOF-MS证实目标物结构正确.
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| 关 键 词： | 手性肽核酸 羟基 咪唑 合成 |
| 收稿时间： | 2005-09-13 |
| 修稿时间： | 2006-03-17 |
Design and Synthesis of New Chiral Peptide Nucleic Acids Containing Hydroxyl and Imidazole Groups |
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| MENG, Qing-Guo,XU, Xiao-Yu,LIANG,Yuan-Jun,LIU, Ke-Liang. Design and Synthesis of New Chiral Peptide Nucleic Acids Containing Hydroxyl and Imidazole Groups[J]. Chinese Journal of Organic Chemistry, 2006, 26(6): 845-847 |
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| Authors: | MENG Qing-Guo XU Xiao-Yu LIANG Yuan-Jun LIU Ke-Liang |
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| Affiliation: | 1School of Pharmacy, Yantai University, Yantai 264005;2 Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850 |
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| Abstract: | Five new 10-mer chiral peptide nucleic acid(PNA)sequences containing hydroxyl and imida-zole groups were designed and synthesized by solid phase synthesis method after the classical PNA mono-mers were replaced by chiral PNA monomers containing serine or histidine residue.The structures of PNA analogues were confirmed by ESI-MS or MALDI-TOF-MS. |
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| Keywords: | chiral peptide nucleic acid hydroxyl group imidazole synthesis |
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