高血压患者左室舒张功能与左室肥厚的关系及随龄改变

为探讨原发性高血压 (以下简称高血压 )患者的左室舒张功能和左室肥厚的关系及其随龄改变 ,抽取 1995年 2月至 2 0 0 2年 7月间门诊高血压患者 4 81例为高血压组 ,以同期体检健康者 2 54 3例为对照组 ,年龄 10～ 80岁 ,并将原发性高血压患者分为 3级 ,每级中按性别分 2组。采用惠普 2 50 0彩色多普勒超声诊断系统检测 2组的室间隔厚度、左室后壁厚度、E/A等指标。使用SPSS软件进行统计学处理分析。结果 :高血压和正常对照组相比E/A显著下降 ,室间隔和左室后壁显著增厚 (P <0 .0 1)。 2个组的E/A均随年龄下降 ,而室间隔厚度随年龄增厚 ,且室间隔厚度和E/A呈显著负偏相关 (P <0 .0 1)。在高血压分级组中 ,Ⅰ～Ⅲ级高血压组中男性的室间隔厚度均厚于女性 (均P <0 .0 1) ,Ⅰ、Ⅱ级高血压组中男性的左室后壁厚度厚于女性 (P <0 .0 5,P <0 .0 1) ,Ⅰ级高血压组中女性的E/A低于男性 (P <0 .0 5)。提示 :左室舒张功能随着年龄的增加而降低 ,而且和高血压左室肥厚呈负偏相关关系 ,性别对其也有一定的影响

Relationship between Left Ventricular Diastolic Function and Left Ventricular Hypertrophy and their Changing with Ages in Essential Hypertensive Patients

The objective was to study the relationship between left ventricular diastolic f unction and left ventricular hypertrophy and their changing with ages in essential hyper tensive patients. Randomly, 3 024 outpatients of hypertension and healthy people were enrolled in Feb 1995 to Jul 2002, including 2 groups from 10 to 80 years old, and als o 481 patients with essential hypertension in three grades were enrolled, includ ing m en and women. Tissue Doppler imaging, and color M-mode echocardiogra phy were used to measure IVST(interventricular septal thickness), and PWT(left v e ntricular posterior wall thickness) and E/A. Compared with control group, E/A w as significantly lower, IVST and PWT were significantly higher( P <0.01). E/A and IVST of the two groups had the same instant changes with ages, and IVST wa s significantly, positively and partially correlated to E/A( P <0.01). In h ypert ension with three degrades, IVST and PWT of men's were significantly higher than that of women. In grade-one hypertension, E/A of women was significantly low er than that of men( P <0.05). The study shows that left ventricular diastoli c function decreases with the increase of ages, and it is positively and partial ly correlated to left ventricular hypertrophy. It is also effected by gender.