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| HSP27、增殖细胞核抗原在视网膜母细胞瘤中的表达 | |
| 引用本文： | 覃冬菊,唐罗生,游庆华,刘湘平.HSP27、增殖细胞核抗原在视网膜母细胞瘤中的表达[J].眼科新进展,2010,30(5). |
| 作者姓名： | 覃冬菊 唐罗生 游庆华 刘湘平 |
| 作者单位： | 1. 浦东新区南汇中心医院眼科,复旦大学附属华山医院南汇分院眼科,上海市,201300 2. 中南大学湘雅二医院眼科,湖南省长沙市,410011 3. 浦东新区南汇中心医院病理科,复旦大学附属华山医院南汇分院病理科,上海市,201300 |
| 摘 要： | 目的探讨热休克蛋白(heat shock proteins,HSP)27、增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在视网膜母细胞瘤(retinoblastoma,Rb)中的表达及其与Rb分化程度和视神经浸润的关系。方法应用鼠抗人HSP27及PCNA的单克隆抗体,采用PV9000二步法免疫组织化学方法,对36例Rb患儿和2例正常对照视网膜组织常规石蜡标本行HSP27及PCNA表达的测定,并分析它们与肿瘤分化程度及视神经浸润的关系。结果HSP27及PCNA在Rb中的表达阳性率分别为69.4%及83.3%;两指标在未分化组阳性表达高于分化组(P<0.05),两指标在视神经浸润组的阳性表达高于未浸润组(P<0.05)。Rb中HSP27的表达与PCNA的表达呈正相关(P<0.01)。结论Rb中HSP27和PCNA的表达与Rb的分化程度、视神经浸润有关。 |
| 关 键 词： | 视网膜母细胞瘤 HSP27 增殖细胞核抗原 免疫组织化学 |
Expressions of HSP27 and PCNA in retinoblastoma |
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| QIN Dong-Ju,TANG Luo-Sheng,YOU Qing-Hua,LIU Xiang-PingFrom the.Expressions of HSP27 and PCNA in retinoblastoma[J].Recent Advances in Ophthalmology,2010,30(5). | |
| Authors: | QIN Dong-Ju TANG Luo-Sheng YOU Qing-Hua LIU Xiang-PingFrom the |
| Affiliation: | QIN Dong-Ju,TANG Luo-Sheng,YOU Qing-Hua,LIU Xiang-PingFrom the Department of Ophthalmology,Nanhui Central Hospital of Pu-dong New District,Shanghai 201300,China,Department of Pathology,Nanhui Central Hospital,Department of Ophthalmology,the Second Xiangya Hospital,Central South University,Changsha 410011,Hunan Province |
| Abstract: | Objective To investigate the expressions of heat shock proteins(HSP)27 and proliferating cell nuclear antigen(PCNA)in retinoblastoma(Rb),and their relations with the degree of differentiation and optic nerve infiltration.Methods The expressions of HSP27 and PCNA in Rb tissues of 36 children and retinal tissues of 2 normal control were analyzed by using PV9000 two steps immunohistochemical method,in which the HSP27 and PCNA monoclonal antibody were applied.The relations between their expressions with tumor d... |
| Keywords: | retinoblastoma HSP27 proliferating cell nuclear antigen immunohistochemistry |
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