Gastric tonometry versus cardiac index as resuscitation goals in septic shock: a multicenter, randomized, controlled trial |
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| Authors: | Fernando Palizas Arnaldo Dubin Tomas Regueira Alejandro Bruhn Elias Knobel Silvio Lazzeri Natalio Baredes Glenn Hernández |
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| Affiliation: | (1) Cl?nica Bazterrica, Unidad de Terapia Intensiva, Billinghurst 2074 (y Juncal), (CP 1425) Buenos Aires, Argentina;(2) Universidad de la Plata, Facultad de Medicina y Ci?ncias Exactas, Calle 115 y 47, CP (1900) La Plata/Buenos Aires, Argentina;(3) Departamento de Medicina Intensiva, Pontificia Universidad Cat?lica de Chile, Marcoleta 367, Santiago, Chile;(4) Hospital Israelita Albert Einstein, Unidad de Terapia Intensiva, Avenida Albert Einstein 627/701, Morumbi, S?o Paulo, Brazil;(5) Hospital Escuela Jos? de San Mart?n, Servicio de Terapia Intensiva, 1250 Rivadavia, Corrientes, Argentina;(6) Hospital de Cl?nicas Jos? de San Mart?n, Unidad de Terapia Intensiva, Av. C?rdoba 2351, Buenos Aires, Argentina |
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| Abstract: | Introduction Resuscitation goals for septic shock remain controversial. Despite the normalization of systemic hemodynamic variables, tissue hypoperfusion can still persist. Indeed, lactate or oxygen venous saturation may be difficult to interpret. Our hypothesis was that a gastric intramucosal pH-guided resuscitation protocol might improve the outcome of septic shock compared with a standard approach aimed at normalizing systemic parameters such as cardiac index (CI). |
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