An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl‐Mediated in situ Activation of α,β‐Unsaturated Carboxylic Acids |
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| Authors: | Yonglei Que Yinan Lu Wenjing Wang Yuhong Wang Haotian Wang Chenxia Yu Tuanjie Li Xiang‐Shan Wang Shide Shen Changsheng Yao |
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| Affiliation: | 1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional, Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, Jiangsu, P. R. China;2. Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu, China |
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| Abstract: | A straightforward N‐heterocyclic carbene (NHC)/LiCl‐mediated synthesis of dihydropyranones from α,β‐unsaturated carboxylic acids and 1,3‐dicarbonyl compounds was realized through the in situ activation strategy. The key advantages of this protocol include ready availability and high stability of starting materials, good yields, and excellent enantioselectivity. |
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| Keywords: | asymmetric synthesis carbenes carboxylic acids dihydropyranones enantioselectivity |
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