| 氟碳化合物FC-77在Pluronic嵌段共聚物胶束中包封与缓释 |
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| 引用本文： | 刘雪峰,王虑,张强,李文放,林兆奋,王俊玲,朱君.氟碳化合物FC-77在Pluronic嵌段共聚物胶束中包封与缓释[J].有机氟工业,2011(3):6-10. |
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| 作者姓名： | 刘雪峰 王虑 张强 李文放 林兆奋 王俊玲 朱君 |
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| 作者单位： | 上海长征医院;纳米技术及应用国家工程研究中心; |
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| 摘 要： | 采用乙醇注入法制备FC-77的载药纳米胶束,通过动态光散射、透射电子显微镜表征了载药纳米胶束的粒径和形貌;通过紫外可见光谱研究了FC-77在嵌段共聚物P123中的包封率和释放曲线。结果表明,含1%P123的FC-77载药纳米胶束粒径为270 nm,呈球形分布,包封率为50%6,00 min时的释放量为92.2%。进一步地,通过调节嵌段共聚物的组成、浓度等可以改变载药纳米胶束的粒径和包封率。结果证明,嵌段共聚物胶束体系能作为FC-77载药制剂的载体,并且通过调整嵌段共聚物胶束体系配方,可以得到理想的FC-77药物载体。
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| 关 键 词： | 氟碳化合物 嵌段聚合物 包封率 缓释 |
Encapsulation and Controlled Release of Perfluoro-compound FC-77 in the Micelle of Pluronic Triblock Copolymer System |
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| Liu Xuefeng,Wang Lv ,Zhang Qiang,Li Wenfang,Lin Zhaofen,Wang Junlin,Zhu Jun.Encapsulation and Controlled Release of Perfluoro-compound FC-77 in the Micelle of Pluronic Triblock Copolymer System[J].Organo-Fluorine Industry,2011(3):6-10. |
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| Authors: | Liu Xuefeng Wang Lv Zhang Qiang Li Wenfang Lin Zhaofen Wang Junlin Zhu Jun |
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| Affiliation: | Liu Xuefeng1,Wang Lv 1,Zhang Qiang1,Li Wenfang1,Lin Zhaofen1,Wang Junlin2,Zhu Jun2(1.Shanghai Changzheng Hospital,Shanghai 200003,China,2.National Engineering Research Center for Nanotechnology,Shanghai 200241,China) |
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| Abstract: | The FC-77-loaded triblock copolymer nanomicelles were prepared by ethanol injection method.The diameters and morphologies of the FC-77-loaded triblock copolymer nanomicelles were characterized using dynamic light scattering and transmission electron microscopy,respectively.Furthermore,the encapsulation efficiencies and the releasing rates of FC-77 were determined by UV-vis spectrum.The results show that the diameter and morphology of FC-77-loaded triblock copolymer nanomicelles in the 1% P123 system were ab... |
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| Keywords: | fluorocarbons block copolymer encapsulation efficiency controlled release |
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