| 紫杉醇及其类似物生产的代谢工程研究进展 |
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| 引用本文： | 余龙江,赵春芳. 紫杉醇及其类似物生产的代谢工程研究进展[J]. 高技术通讯, 2003, 13(1): 106-110 |
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| 作者姓名： | 余龙江 赵春芳 |
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| 作者单位： | 华中科技大学生命科学与技术学院,武汉,430074 |
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| 基金项目： | 教育部 2 0 0 0年高等学校骨干青年教师基金资助项目。 |
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| 摘 要： | 大量生产抗癌新药紫杉醇是目前生物技术的研究热点之一。通过对紫杉醇生物合成途径中关键酶基因的分离、克隆与遗传转化等方面最新研究结果进行评述 ,指出通过紫杉醇次生代谢途径中关键酶的基因改造及遗传转化 ,构建高效表达紫杉醇或其重要前体紫杉烷的基因工程细胞株 ,并建立其相应的基因表达调控方法 ,是解决紫杉醇药源问题的最有前途的方法之一。
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| 关 键 词： | 紫杉醇生物合成 植物次生代谢工程 基因工程 |
| 修稿时间： | 2002-09-06 |
Advances in the Secondary Metabolic Engineering of the Production for Taxol and Taxanes |
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| Yu Longjiang Zhao Chunfang. Advances in the Secondary Metabolic Engineering of the Production for Taxol and Taxanes[J]. High Technology Letters, 2003, 13(1): 106-110 |
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| Authors: | Yu Longjiang Zhao Chunfang |
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| Abstract: | The sustainable supply problem of taxol has been becoming one of the hottest topic of biotechnology. Through the analysis of the latest research results on the isolation and cloning and transformation in Taxus sp. of the genes of key enzymes related with taxol biosynthesis, the authors consider that taxol secondary metabolic engineering can provide a promising solution to the sustainable supply problem with taxol and its related taxanes expressed in high efficiency and stably in recombinant cells constituted by modifying and transforming the key enzyme genes. |
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| Keywords: | Taxol biosynthesis Plant secondary metabolic engineering Genetic engineering |
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