通心络胶囊对急性心梗PCI术后心肌微循环及心功能的影响

目的:探讨通心络胶囊对急性心梗经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后心肌微循环及心功能的影响。方法:选取2014年1月-2017年6月我院收治的ST段抬高型急性心肌梗死需经PCI患者200例,按照治疗方法分为对照组、观察组,每组100例。对照组进行常规药物治疗,观察组联合通心络胶囊进行治疗。比较两组PCI后心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)血流分级与计帧值(corrected thrombolysis in myocardial frame count,CTFC)、ST段回落情况、肌酸磷酸激酶同工酶(creatine phosphokinase-isoenzyme-MB,CK-MB)峰值及峰值时间,治疗前后心功能相关指标的变化。结果:PCI术后,两组冠脉TIMI血流分级比较差异不显著(P0.05),观察组CFTC显著低于对照组(P0.05),观察组ST段回落50%比例显著高于对照组(P0.05),CK-MB峰值及CK-MB峰值时间显著低于对照组(P0.05)。治疗后,两组左室射血分数(left ventricular ejection fraction,LVEF)、心脏指数(cardiac index,CI)均显著升高(P0.05)左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、左心室收缩末期内径(left ventricular end-systolic dimension,LVESD)均显著降低(P0.05),且观察组的以上指标的改善明显优于对照组(P0.05)。结论:通心络胶囊在急性心梗PCI后患者的应用中临床疗效良好,能够改善心肌微循环和心功能。

Effect of Tongxinluo Capsule on the Myocardial Microcirculation and Cardiac Function of patients with Acute Myocardial Infarction after PCI

ABSTRACT Objective: To explore the effect of Tongxinluo capsule on the myocardial microcirculation and cardiac function of patients with acute myocardial infarction after PCI. Methods: 200 cases of patients with ST-segment elevation acute myocardial infarction required PCI in our hospital from January 2014 to June 2017 were selected and divided into the control group and the observation group according to the treatment methods, with 100 cases in each group. The control group was given conventional drug treatment, while the observation group was given Tongxinluo capsule on the basis of control group. The TIMI grade and CTFC, ST-segment depression, CK-MB peak and peak time, changes of cardiac function related indexes were compared between two groups before and after treatment. Results: There was no significant difference in the TIMI grading between two groups after PCI(P>0.05). The CFTC in observation group was significantly lower than that in the control group (P<0.05). The percentage of ST-segment depression >50% in observation group was significantly higher than that in the control group after PCI (P<0.05). The CK-MB peak and CK-MB peak time of observation group were significantly lower than those of the control group (P<0.05). The LVEF and CI in both groups were significantly increased after treatment (P<0.05). The LVEDD, LVESD in both groups were significantly declined after treatment (P<0.05). The improvement of observation group was obviously better than that of control group (P<0.05). Conclusion: Tongxinluo capsule had good clinical effect in the treatment of patients with acute myocardial infarction, it can improve the myocardial microcirculation and cardiac function.