马普替林对CUMS抑郁模型大鼠血清铜锌钙镁含量的影响

目的探讨部分金属元素铜、锌、钙、镁与抑郁症之间的关系。方法健康雄性SD大鼠36只,随机分为3组。采用Katz刺激方法制备CUMS抑郁模型。结果采用孤养和CUMS刺激方法成功制备动物抑郁模型。模型组血清铜含量较正常组明显升高、模型组血清锌含量较正常组明显降低;而马普替林组较模型组比较均能够逆转上述改变;关于钙和镁未发现其差异性。结论微量元素锌和铜与抑郁症密切相关,其机制可能与突触可塑性、内分泌、神经递质等因素相关。

Maprotiline's influences on the level of plasm copper, zinc, calcium and magnesium in the chronic unpredictable mild stress depression model of rats

Objective To study the relation between depression and copper,zinc,calcium and magnesium.Methods Thirty-six male rats were randomly divided into 3 groups.Katz stimulation method was used to create CUMS depression model.The level of serum Copper and Zinc were detected by atomic absorption method.The level of serum calcium and magnesium were detected by Arsenazo Ⅲ and MTB.Results The depression model was successfully created.Compared with control animals,the serum copper level of the model rat increased significantly and the serum zinc level decreased significantly in depression rats.The Maprotiline group can reverse these changes compared to the model group.The change of the serum calcium and magnesium level had no significant deviation.Conclusion Microcontent elements of copper and zinc are closely related to depression.This mechanism may be related to synaptic plasticity,endocrine and neurotransmitters etc.