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聚甲基丙烯酸甲酯骨水泥对心血管系统影响及其预防的文献分析
引用本文:白海蓬,宋立刚,闵昌敏,王琪. 聚甲基丙烯酸甲酯骨水泥对心血管系统影响及其预防的文献分析[J]. 中国药物警戒, 2007, 4(2): 100-103
作者姓名:白海蓬  宋立刚  闵昌敏  王琪
作者单位:天津市药品不良反应监测中心,天津,300070
摘    要:目的综述关节置换术中聚甲基丙烯酸甲酯骨水泥对“血管系统的影响及预防措施,为其安全性评价和监管提供依据。方法对检索到的国内骨水泥文献筛选归纳并进行描述性分析。结果关节置换术中骨水泥易产生心血管系统并发症,导致血压下降、心律失常、血栓、肺栓塞等。结论文献分析结果表明,骨水泥的临床应用存在一定的安全性问题,建议临床医生谨慎使用。

关 键 词:聚甲基丙烯酸甲酯  骨水泥  心血管系统  综述
文章编号:1672-8629(2007)02-0100-04
修稿时间:2007-02-02

The literatures analysis of the cardiovascular disturbance and prevention of the PMMA bone cement
BAI Hai-peng,SONG Li-gang,MIN Chang-min,WANG Qi. The literatures analysis of the cardiovascular disturbance and prevention of the PMMA bone cement[J]. Chinese JOurnal of Pharmacovigilance, 2007, 4(2): 100-103
Authors:BAI Hai-peng  SONG Li-gang  MIN Chang-min  WANG Qi
Affiliation:Tianjin Center for ADR Monitoring,Tianjin 300070,China
Abstract:Objective Describe the cardiovascular disturbance and prevention of the Polymethylmethacrylate(PMMA)bone cement in the joint-displacement operation to provide evidence for the safety evaluation and supervision.Method Analyze the domestic literatures by screening and classification.Result Bone cement in the joint-displacement operation easily lead the occurrence of cardiovascular complication as hypotension,arrhythmia,thrombus,lung-embolism and so on.Conclusion The literatures suggest that the risk exist in the clinical application and the surgeon use it cautiously.
Keywords:Polymethylmethacrylate   bone   cement   cardiovascular   overview
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