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Antigen-driven PD-1+TOX+BHLHE40+ and PD-1+TOX+EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ |
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| Authors: | Patrick Maschmeyer Gitta Anne Heinz Christopher Mark Skopnik Lisanne Lutter Alessio Mazzoni Frederik Heinrich Sae Lim von Stuckrad Lorenz Elias Wirth Cam Loan Tran René Riedel Katrin Lehmann Imme Sakwa Rolando Cimaz Francesco Giudici Marcus Alexander Mall Philipp Enghard Bas Vastert Hyun-Dong Chang Pawel Durek Francesco Annunziato Femke van Wijk Andreas Radbruch Tilmann Kallinich Mir-Farzin Mashreghi |
| Affiliation: | 1. Deutsches Rheuma-Forschungszentrum (DRFZ), Institute of the Leibniz Association, Berlin, Germany;2. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Intensive Care Medicine, Berlin, Germany;3. Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands;4. Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, Florence, Italy;5. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin SPZ (Center for Chronically Sick Children), Berlin, Germany;6. Anna Meyer Children's Hospital and University of Florence, Florence, Italy Department of Clinical Sciences and Community Health, University of Milano, Milano, Italy;7. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy;8. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany;9. Deutsches Rheuma-Forschungszentrum (DRFZ), Institute of the Leibniz Association, Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Equal senior authorship. |
| Abstract: | |
| Keywords: | BHLHE40 chronic inflammation PD-1 EOMES juvenile idiopathic arthritis T cells TOX |
