刺激杏仁基底外侧核对外侧缰核神经元单位放电的影响

用玻璃微电极细胞外记录大鼠外侧缰核(LHN)神经元的单位放电。共记录了110个神经元。其中痛兴奋神经元(LHPE)75个;痛抑制神经元(LHPI)11个;广动力型神经元2个;无反应神经元17个;此外还有5个对躯体与内脏伤害性刺激反应不同的神经元。电刺激杏仁基底外侧核(以下简称杏仁核,AMG)对LHPE和LHPI的自发放电主要产生抑制作用,分别占总数的81.1％和72.7％,并抑制其对伤害性刺激的反应;对无反应神经元和广动力型神经元无明显影响。AMG内微量注射吗啡能抑制LHPE的伤害性刺激反应,但对其自发放电无明显影响。微量注射纳洛酮则可增加LHPE的自发放电频率,并加强其对伤害性刺激的反应。注射纳洛酮还可以取消电针对LHPE的伤害性刺激反应的抑制作用。

EFFECT OF STIMULATION OF BASOLATERAL AMYGDALOID NUCLEUS ON UNIT DISCHARGES OF NEURONS OF HABENULAR NUCLEUS

In 46 albino rats under chloral hydrate anesthesia, 110 neurons of lateralhabenular nucleus (LHN) were extracellularly recorded. Spontaneous dischargefrequencies were increased in 75 neurons (LHPE), decreased in 11 (LHPI),unchanged in 17 (pain-nonsensitive neurons) by both somatic and visceralnoxious stimulation; 2 neurons (wide-dynamic neurons) were activated by eithernoxious stimulation or non-noxious stimulation; 5 neurons had different responsesto somatic and visceral noxious stimulation. Spontaneous discharge frequencies of LHPE and LHPI neurons were decrea-sed and the nociceptive responses of them were inhibited by stimulation of basolate-ral amygdoloid nucleus (AMG). There was no effect of stimulation of AMGon pain-nonsensitive neurons and wide -dynamic neurons of LHN. Microinjection of morphine into AMG could inhibit the nociceptive responsesof LHPE. Intra-amygdaloid naloxone injection could increase the frequency ofspontaneous discharges of LHPE and intensify its nociceptive responses. Microin-jection of naloxone could also relieve the inhibitory effect of electroacupuncture onnociceptive responses of LHPE.