| 外阴硬化萎缩性苔藓与外阴鳞状细胞癌的基因研究 |
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| 引用本文： | 叶缘苑,高进. 外阴硬化萎缩性苔藓与外阴鳞状细胞癌的基因研究[J]. 国际皮肤性病学杂志, 2007, 33(3): 157-159 |
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| 作者姓名： | 叶缘苑 高进 |
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| 作者单位： | 1. 430022,武汉,湖北中医学院中医系
2. 武汉市第一医院皮肤科 |
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| 摘 要： | 外阴硬化萎缩性苔藓是较为常见的一种慢性皮肤黏膜病变，部分患者可能发展为外阴鳞状细胞癌。近年来的研究发现，外阴硬化萎缩性苔藓可能与多种癌基因、抑癌基因突变及其表达异常存在着密切联系。综述与外阴硬化萎缩性苔藓和外阴鳞状细胞癌相关的十余种癌基因与抑癌基因，分析从外阴硬化萎缩性苔藓发展到外阴鳞状细胞癌的因素。
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| 关 键 词： | 外阴硬化性苔藓 癌 鳞状细胞 癌基因 |
| 修稿时间： | 2006-07-06 |
Genes related to lichen sclerosus et atrophicus and squamous cell carcinoma of vulva |
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| YE Yuan-yuan,GAO Jin. Genes related to lichen sclerosus et atrophicus and squamous cell carcinoma of vulva[J]. International Journal of Dermatology and Venereology, 2007, 33(3): 157-159 |
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| Authors: | YE Yuan-yuan GAO Jin |
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| Affiliation: | Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, China |
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| Abstract: | Lichen sclerosus et atrophicus (LSA)is a kind of chronic skin mucous disease, and often develop into vulvar squamous cell carcinoma(VSCC). Recently, it has been shown that many oncogenes and anti-oncogenes are closely related to the transformation of LSA to VSCC. This article reviews LSA- and VSCC-related oncogenes and anti-oncogenes,such as p53, bcl-2/bax, p16, EGFR, HPV and hTERT, and analyzes the genetic reasons in transformation process from LSA to VSCC. |
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| Keywords: | Vulvar lichen sclerosus Carcinoma, squamous cell Oncogenes |
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