Cyclin E和p57kip2在卵巢上皮性肿瘤中的表达及意义

目的:研究细胞周期蛋白Cyclin E和细胞周期蛋白依赖性激酶的抑制因子p57kip2在不同卵巢上皮肿瘤中的表达情况及临床意义。方法:应用免疫组化S-P法检测Cyclin E和p57kip2在正常卵巢组织(8例)、良性肿瘤(12例)、交界性肿瘤(20例)和恶性肿瘤(20例)中的表达情况,分析两指标的相关性及临床意义。结果:①CyclinE的阳性表达率随正常卵巢组织、良性肿瘤、交接性肿瘤、恶性肿瘤的进展程度显著升高;p57kip2的表达则相反,两者呈负相关(P<0.05);②Cyclin E的表达与卵巢恶性肿瘤的临床分级、组织学分化及周围组织浸润有关(P<0.05);p57kip2的表达与恶性肿瘤的组织学分化有关,与临床分级及周围组织浸润无关。结论:Cyclin E和p57kip2的表达水平与卵巢上皮性肿瘤的发生、发展及恶性程度有关,Cyclin E的高表达和p57kip2的低表达可能是恶性卵巢上皮瘤的一对重要的生物学指标,对预测卵巢肿瘤的恶性程度及预后有指导意义。

The expression and significance of Cyclin E and p57kip2 in epithelial tumor of ovary

Objective:To investigate the expression of Cyclin E and p57kip2 in different epithelial ovarian tumor and their significance in clinic.Methods:Immunohistochemical analysis was used to detect the expression of Cyclin E and p57kip2 in 8 cases of normaltissue,12 cases of benign ovarian tumor,20 cases of SOBT and 20 cases of ovarian cancer,and analyzed the relationship between the indicators and their clinical significance.Results:①The positive ratio of Cyclin E expression was increased from the normal tissue to benign to borderline to ovarian cancer.On the contrary,the expression of p57kip2 was reduced clearly.There was negative relationship between them.②The expression of Cyclin E in ovarian cancer was correlated with its stage,grade and axillary(P<0.05).The expression of p57kip2 was correlated with the stage and had no correlated with grade and axillary.Conclusion:The expression of Cycline E and p57kip2 are correlated to the occurrence,progression and malignancy of ovarian cancer,they may be the potential important tumor markers for evaluating malignancy and prognosis of ovarian cancer.